Evidence map›Paper›PMID 39769363›Full record

ArticleInternational journal of molecular sciences2024

Micellar Choline-Acetyltransferase Complexes Exhibit Ultra-Boosted Catalytic Rate for Acetylcholine Synthesis-Mechanistic Insights for Development of Acetylcholine-Enhancing Micellar Nanotherapeutics.

Davide Dante, Jatin Jangra, Anurag T K Baidya, Rajnish Kumar, Taher Darreh-Shori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Davide DanteDivision of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 57 Stockholm, Sweden.
Jatin JangraDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi 221005, India.
Anurag T K BaidyaDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi 221005, India.
Rajnish KumarDepartment of Pharmaceutical Engineering & Technology, Indian Institute of Technology (B.H.U.), Varanasi 221005, India.ORCID 0000-0002-7021-6996
Taher Darreh-ShoriDivision of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 57 Stockholm, Sweden.ORCID 0000-0003-1176-6258

Funding

Åhlén-Foundation xAlzheimer´s Association AARG-24-1310046Dementia Foundation (Demensfonden) xFoundation for Old Servants (Gamla Tjänarinnor) xgrant from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement ALF Med N 20200330Gun and Bertil Stohnes Foundation xKarolinska Institutet´s Research Foundations xMagnus Bergvalls Foundation xOlle Engkvist Byggmästare Foundation 211-0100Swedish Medical Research Council VR 2017-06086
6 · The paper itself

Abstract

Choline-acetyltransferase (ChAT) is the key cholinergic enzyme responsible for the biosynthesis of acetylcholine (ACh), a crucial signaling molecule with both canonical neurotransmitter function and auto- and paracrine signaling activity in non-neuronal cells, such as lymphocytes and astroglia. Cholinergic dysfunction is linked to both neurodegenerative and inflammatory diseases. In this study, we investigated a serendipitous observation, namely that the catalytic rate of human recombinant ChAT (rhChAT) protein greatly differed in buffered solution in the presence and absence of Triton X-100 (TX100). At a single concentration of 0.05% (

Indexed as

AcetylcholineCholine O-AcetyltransferaseMicellesAcetylcholinesteraseCatalysisHumansMolecular Dynamics SimulationNanoparticlesOctoxynolRecombinant ProteinsAcetylcholineAcetylcholinesteraseCholine O-AcetyltransferaseMicellesOctoxynolRecombinant Proteinsacetylcholine (ACh)acetylcholinesterase (AChE)catalytic rateChAT–micelle nanoparticlescholine-acetyltransferase (ChAT)cholinergic signalingcritical micelle concentration (CMC)non-ionic surfactants/detergentsTriton X-100Tween 20

Identifiers

PMID39769363
PMCPMC11679501

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.