ArticleInternational journal of molecular sciences2024
Fine-Tuned Expression of Evolutionarily Conserved Signaling Molecules in the
Lenny J Negrón-Piñeiro, Yushi Wu, Ravij Mehta, Julie E Maguire, Cindy Chou, Joyce Lee, Chitra L Dahia, Anna Di Gregorio
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Lenny J Negrón-PiñeiroDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
Yushi WuDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
Ravij MehtaOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.ORCID 0000-0001-9645-8929 Julie E MaguireDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
Cindy ChouDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
Joyce LeeDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.
Chitra L DahiaOrthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY 10021, USA.
Anna Di GregorioDepartment of Molecular Pathobiology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA.ORCID 0000-0003-4089-7484 Funding
Role of Developmental Signaling Pathways in Maintenance of Spinal DiscsR01AG070079 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI Chitra L Dahia · 2021 to 2026
$3.3MRole of Shh/Brachyury axis in the maintenance of the postnatal intervertebral discR01AR077145 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI DAHIA, CHITRA L · 2021 to 2025
$3.0MControl of precisely timed gene expression during notochord development by BrachyuryR01GM149841 · NIGMS · NEW YORK UNIVERSITY · PI ANNA DI GREGORIO · 2024 to 2026
$966kElucidation of a Brachyury-independent branch of the notochord gene regulatory networkR03HD107314 · NICHD · NEW YORK UNIVERSITY · PI DI GREGORIO, ANNA · 2022 to 2023
$161kFluorescent StereomicroscopeS10OD026763 · OD · HOSPITAL FOR SPECIAL SURGERY · PI DAHIA, CHITRA L · 2019 to 2019
$60kNIAMS NIH HHS R01 AR077145NIA NIH HHS R01 AG070079NICHD NIH HHS R03 HD107314NIGMS NIH HHS R01 GM149841NIGMS NIH HHS R01GM149841NIH HHS S10 OD026763
6 · The paper itselfAbstract
The notochord is an axial structure required for the development of all chordate embryos, from sea squirts to humans. Over the course of more than half a billion years of chordate evolution, in addition to its structural function, the notochord has acquired increasingly relevant patterning roles for its surrounding tissues. This process has involved the co-option of signaling pathways and the acquisition of novel molecular mechanisms responsible for the precise timing and modalities of their deployment. To reconstruct this evolutionary route, we surveyed the expression of signaling molecules in the notochord of the tunicate
Indexed as
CionaEvolution, MolecularGene Expression Regulation, DevelopmentalNotochordSignal TransductionAnimalsCiona intestinalisTransforming Growth Factor betaTransforming Growth Factor betaascidianBrachyuryCionacis-regulatory moduleCtgfenhancernotochordRac1semaphorinsignaling moleculeTgf-β
Identifiers
PMID39769393
PMCPMC11728170
What Socratic holds
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