ArticleInternational journal of molecular sciences2024
Sucralose-Enhanced Adipogenesis on Preadipocyte Human Cell Line During Differentiation Process.
Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- High-Dose Sucralose Is Associated With Lacrimal Circadian Remodeling, Reduced Immunometabolic Signatures, and Reduced Tear Secretion.Investigative ophthalmology & visual science · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sucralose, a commonly nonnutritive sweetener used in daily products of habitual diet, is related to impairing the gut microbiome by disrupting inflammatory response, promoting weight gain by increasing adipose tissue and promoting chronic inflammatory processes. Considering the impact of sucralose in the development of metabolic diseases, in this work, we focused on the impact of sucralose on the adipocyte differentiation process to determine if sucralose can promote adipogenesis and increase adipose tissue depots in PCS 210 010 human preadipocytes cell line. Sucralose at 25 (S25) and 100 ng/µL (S100) concentrations were tested against control with no edulcorant (NS) during the adipocyte differentiation process at 48 h and 96 h. The genetic expression of adipogenesis markers such as CEBP-α, PPARγ, EBF-2, UCP-1, and lipogenesis regulator ACC was determined by qPCR. A panel of human cytokines related to inflammatory response was measured by a flow cytometer using the kit Legend Plex Human Cytokine panel of BIOLUMINEX. Our results indicate that sucralose increased the expression of white adipocyte differentiation marker CEBP-α and lipogenesis regulator ACC at 96 h before complete differentiation. Also, sucralose triggers an inflammatory response by synthesizing adiponectin, resistin, IL-6, IL-8, and Il-1B. To summarize, sucralose stimulates the expression of genes related to adipogenesis and negatively affects the secretion of inflammatory cytokines and adipokines during preadipocyte differentiation.
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