Evidence map›Paper›PMID 39769460›Full record

ArticleInternational journal of molecular sciences2024

Microbubble-Protected Oncolytic Virotherapy Targeted by Sonoporation Induces Tumor Necrosis and T-Lymphocyte Infiltration in Humanized Mice Bearing Triple-Negative Breast Cancer.

Juliana Sitta, Flavia De Carlo, Imani Kirven, John H Tackett, Patrice Penfornis, George Clement Dobbins, Mallory Barbier, Luis Del Valle, Clayton T Larsen, Ernest G Schutt and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Engineering microspheres for breast cancer: integrating tumor modeling, diagnostics, and targeted treatment.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juliana SittaDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-6585-8433
Flavia De CarloDepartment of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Imani KirvenDepartment of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
John H TackettDepartment of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0009-0000-2229-9005
Patrice PenfornisDepartment of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-7703-0070
George Clement DobbinsDepartment of Neurosurgery and Bioinformatics, University of Alabama Birmingham, Birmingham, AL 35205, USA.
Mallory BarbierDepartment of Pathology, Louisiana Cancer Research Center, Louisiana State University Health, New Orleans, LA 70112, USA.
Luis Del ValleDepartment of Pathology, Louisiana Cancer Research Center, Louisiana State University Health, New Orleans, LA 70112, USA.ORCID 0000-0003-3894-9206
Clayton T LarsenVesselon, Inc., Norwalk, CT 06851, USA.
Ernest G SchuttVesselon, Inc., Norwalk, CT 06851, USA.
Rhodemann LiVesselon, Inc., Norwalk, CT 06851, USA.
Candace M HowardDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-6537-3551
Pier Paolo ClaudioDepartment of Pharmacology & Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-7790-1622

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI Arunava Roy · 2017 to 2026
$22.4M
NIGMS NIH HHS P20 GM121288NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428Vesselon Vesselon grant
6 · The paper itself

Abstract

Oncolytic virotherapy has shown great promise in mediating targeted tumor destruction through tumor-selective replication and induction of anti-tumor immunity; however, obstacles remain for virus candidates to reach the clinic. These include avoiding neutralizing antibodies, preventing stimulation of the adaptive immune response during intravenous administration, and inducing sufficient apoptosis and immune activation so that the body's defense can work to eradicate systemic disease. We have developed a co-formulation of oncolytic viruses (OVs) with Imagent

Indexed as

MicrobubblesOncolytic VirotherapyOncolytic VirusesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleHumansLymphocytes, Tumor-InfiltratingMiceNecrosisT-LymphocytesXenograft Model Antitumor Assayscavitationgene therapyimmunotherapymicrobubblesmicrospheresoncolytic virusultrasoundultrasound contrast agent

Identifiers

PMID39769460
PMCPMC11678396

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.