Evidence map›Paper›PMID 39770078›Full record

ReviewMolecules (Basel, Switzerland)2024

The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers.

Estera Okoń, Wirginia Kukula-Koch, Agata Jarząb, Katarzyna Gaweł-Bęben, Ewelina Bator, Magdalena Michalak-Tomczyk, Jacek Jachuła, Beata Antosiewicz-Klimczak, Adrian Odrzywolski, Wojciech Koch and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rhein and its derivatives: potential anti-tumor drugs and corresponding targeted mechanism.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Estera OkońDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.ORCID 0000-0003-3810-8247
Wirginia Kukula-KochDepartment of Pharmacognosy with Medical Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.ORCID 0000-0001-7076-600X
Agata JarząbDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
Katarzyna Gaweł-BębenDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego, 35-225 Rzeszów, Poland.ORCID 0000-0001-5773-1849
Ewelina BatorInterdisciplinary Center for Preclinical and Clinical Research, Rzeszow University, 2a Werynia, 36-100 Kolbuszowa, Poland.ORCID 0000-0001-5510-7938
Magdalena Michalak-TomczykDepartment of Physiology and Toxicology, The John Paul II Catholic University of Lublin, 1I Konstantynów Str., 20-708 Lublin, Poland.ORCID 0000-0002-2244-4118
Jacek JachułaDepartment of Botany, Mycology and Ecology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 19 Akademicka Str., 20-033 Lublin, Poland.ORCID 0000-0001-8949-776X
Beata Antosiewicz-KlimczakDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego, 35-225 Rzeszów, Poland.
Adrian OdrzywolskiDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.ORCID 0000-0002-3370-8801
Wojciech KochDepartment of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland.ORCID 0000-0001-8749-9657
Anna WawruszakDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.ORCID 0000-0003-2388-4577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary and metastatic tumors of the nervous system represent a diverse group of neoplasms, each characterized by distinct biological features, prognostic outcomes, and therapeutic approaches. Due to their molecular complexity and heterogeneity, nervous system cancers (NSCs) pose significant clinical challenges. For decades, plants and their natural products with established anticancer properties have played a pivotal role in the treatment of various medical conditions, including cancers. Anthraquinone derivatives, a class of tricyclic secondary metabolites, are found in several botanical families, such as

Indexed as

AnthraquinonesAnimalsAntineoplastic AgentsAntineoplastic Agents, PhytogenicApoptosisEmodinHumansSignal TransductionAnthraquinonesAntineoplastic AgentsAntineoplastic Agents, PhytogenicEmodin1,8-dihydroanthraquinone derivativesaloe-emodinbiological activitychrysophanolemodinhypericinnatural productsnervous system cancersphyscionrhein

Identifiers

PMID39770078
PMCPMC11677425

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.