Evidence map›Paper›PMID 39770361›Full record

ArticlePathogens (Basel, Switzerland)2024

FISH-Flow Cytometry Reveals Microbiome-Wide Changes in Post-Translational Modification and Altered Microbial Abundance Among Children with Inflammatory Bowel Disease.

Mevlut Ulas, Seamus Hussey, Annemarie Broderick, Emer Fitzpatrick, Cara Dunne, Sarah Cooper, Anna Dominik, Billy Bourke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mevlut UlasDepartment of Paediatrics, University College Dublin, CHI-Crumlin, D12 N512 Dublin, Ireland.ORCID 0000-0001-9284-8727
Seamus HusseyDepartment of Paediatrics, University College Dublin, CHI-Crumlin, D12 N512 Dublin, Ireland.
Annemarie BroderickDepartment of Paediatrics, University College Dublin, CHI-Crumlin, D12 N512 Dublin, Ireland.
Emer FitzpatrickDepartment of Paediatrics, University College Dublin, CHI-Crumlin, D12 N512 Dublin, Ireland.
Cara DunneDepartment Gastroenterology, CHI-Crumlin, D12 N512 Dublin, Ireland.
Sarah CooperNational Children's Research Center, CHI-Crumlin, D12 N512 Dublin, Ireland.ORCID 0009-0009-4845-0434
Anna DominikNational Children's Research Center, CHI-Crumlin, D12 N512 Dublin, Ireland.
Billy BourkeDepartment of Paediatrics, University College Dublin, CHI-Crumlin, D12 N512 Dublin, Ireland.

Funding

Children's Medical and Research Foundation Dublin C/19/1
6 · The paper itself

Abstract

Metaproteomic analysis of microbiome post-translation modifications (PTMm) is challenging, and little is known about the effects of inflammation on the bacterial PTM landscape in IBD. Here, we adapted and optimised fluorescence in situ hybridisation-flow cytometry (FISH-FC) to study microbiome-wide tyrosine phosphorylation (p-Tyr) in children with and without inflammatory bowel disease (IBD). Microbial p-Tyr signal was significantly higher in children with IBD, compared to those without.

Indexed as

Flow CytometryGastrointestinal MicrobiomeInflammatory Bowel DiseasesIn Situ Hybridization, FluorescenceProtein Processing, Post-TranslationalAdolescentBacteriaChildChild, PreschoolFecesFemaleHumansMaleMicrobiotaPhosphorylationTyrosineTyrosinechildFISH–flow cytometryinflammatory bowel diseasemicrobiomepost-translational modificationtyrosine phosphorylation

Identifiers

PMID39770361
PMCPMC11728554

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.