Evidence map›Paper›PMID 39770987›Full record

Trial reportNutrients2024

Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Randomized Controlled Trial.

Kok Ming Goh, Eugenie Sin Sing Tan, Crystale Siew Ying Lim, Pui Yee Tan, Sayantan Biswas, Li Ann Lew, Chung Keat Tan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kok Ming GohNew Product Development Department, Ecolite Biotech Manufacturing, Yong Peng 83400, Malaysia.
Eugenie Sin Sing TanFaculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0001-5711-4808
Crystale Siew Ying LimFaculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-0517-0610
Pui Yee TanFaculty of Environment, University of Leeds, Leeds LS2 9JT, UK.
Sayantan BiswasSchool of Optometry, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.ORCID 0000-0001-6011-0365
Li Ann LewProduct Development Department, Xmegami Manufacturing, Puchong 47170, Malaysia.
Chung Keat TanFaculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-3956-2217

Funding

Ministry of Higher Education FRGS/1/2022/SKK06/UCSI/02/2UCSI University REIG-FMHS-2024/022UCSI University REIG-FMHS-2024/025
6 · The paper itself

Abstract

BACKGROUND/

objectivesDry eye disease (DED) significantly impairs quality of life, affecting physical, social, and psychological well-being, as well as reducing workplace productivity. While lutein and zeaxanthin supplements have been shown to improve ocular health, existing research often overlooks the efficacy of lower dosages and shorter durations of supplementation. This study investigated the effects of combined supplementation with lutein, zeaxanthin, and elderberries in 110 voluntary participants through a randomized controlled trial.

methodsParticipants took 6 mg of lutein and 1 mg of zeaxanthin, along with 100 mg elderberry extract once daily for a duration of 20 days. Ocular health was assessed using the Ocular Surface Disease Index (OSDI), while immune status was evaluated with the Immune Status Questionnaire (ISQ).

resultsResults showed that combined supplementation significantly (

conclusionsCollectively, these findings support the use of combined supplementation as an adjuvant approach to improving ocular health.

Indexed as

Dietary SupplementsDry Eye SyndromesLuteinZeaxanthinsAdultAgedFemaleHumansMaleMiddle AgedPlant ExtractsQuality of LifeSurveys and QuestionnairesLuteinPlant ExtractsZeaxanthinselderberriesImmune Status Questionnaire (ISQ)luteinOcular Surface Disease Index (OSDI)zeaxanthin

Identifiers

PMID39770987
PMCPMC11679324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.