Observational studyJournal of the American College of Cardiology2025
Myocardial Fibroblast Activation After Acute Myocardial Infarction: A Positron Emission Tomography and Magnetic Resonance Study.
2 registry-linked trialsAbstract readObservational Study
In one paragraph
Observational study in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROline and FapI With Late Gadolinium Enhancement in Myocardial Infarction PROFILE-MI - The FAPI Fibrosis Study
FAPl Imaging Assessment of Revascularization Outcome in Ischemic Heart Failure
Who cites it
29 citing papers in PubMed.
- Cardiac MR Characterization of Infarct-Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Cardiac fibrosis: mechanistic insights and translational advances.Molecular biomedicine · 2026Review
- Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026Review
- Unveiling silent CAD in an oncology patient: stress delayed defect filling of [¹⁸F]Flurpiridaz as a potential viability biomarker.European journal of nuclear medicine and molecular imaging · 2026Article
- FAPI PET/CT in post-PCI coronary disease: in-stent restenosis characterization, MACE association, and limited short-term modulation by lipid-lowering therapy: FAPI athero trial.European journal of nuclear medicine and molecular imaging · 2026Observational
- Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026Review
- Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies.Pharmacological reviews · 2026Review
- Molecular Imaging of Collagen Turnover in Myocardial Infarction.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Comparison of the distribution and functional significance of myocardial fibroblast activation and inflammation in reperfused ST-elevation myocardial infarction.Quantitative imaging in medicine and surgery · 2026Article
- Molecular imaging of immune and fibrosis targets to guide therapy for repair after myocardial infarction.Nature reviews. Cardiology · 2026Review
- Glabridin improves cardiac remodeling after myocardial infarction by activating PPARγ to regulate the ubiquitination and degradation of EGFR.Biology direct · 2026Article
- Machine Learning-Informed Nano Co-Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- The molecular symphony of myocardial repair: RGD, FAPI, and granzyme B PET in concert.European journal of nuclear medicine and molecular imaging · 2026Article
- Endothelial-to-Mesenchymal Transition in Post-Myocardial Infarction Fibrosis: A Maladaptive but Targetable Pathway.EJIFCC · 2026Review
- Aerobic exercise reduces lactate accumulation and improves cardiac function after myocardial infarction.Frontiers in medicine · 2026Article
- NF-Frontiers in cardiovascular medicine · 2026Review
- Early in-hospital initiation of angiotensin-receptor-neprilysin inhibitor in post-acute myocardial infarction patients with impaired left ventricular systolic function: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Article
- Molecular contrast agents for post-infarct cardiac remodelling: a contemporary review.European heart journal. Imaging methods and practice · 2026Review
- Predictors of right ventricular dysfunction and its clinical value after reperfusion of acute right coronary artery occlusion: a single-center retrospective analysis.American journal of translational research · 2026Article
- [European journal of nuclear medicine and molecular imaging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Anna K BartonBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom. Electronic address: abarton3@ed.ac.uk.
Neil J CraigBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Krithika LoganathBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Shruti JoshiBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Vasiliki TsampasianNorwich Medical School, University of East Anglia, Norwich, United Kingdom.
Menaka MahendranBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Joel LenellUppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Evangelos TzolosBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Trisha SinghBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom; Department of Cardiology, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, United Kingdom.
Beth WhittingtonBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Jennifer NashBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Michelle C WilliamsBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Edwin J R van BeekEdinburgh Imaging Facility, Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom.
Mark G MacAskillBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Bronwyn BerkeleyBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Stefan VezaidesBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Mairi BrittanBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Andrew H BakerBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Stephanie SellersDepartment of Radiology and Centre for Heart Lung Innovation, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Alison FletcherEdinburgh Imaging Facility, Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom.
Tim ClarkEdinburgh Imaging Facility, Queen's Medical Research Institute, Edinburgh, Scotland, United Kingdom.
Clint WaightNHS Lothian, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom.
Riemer H J A SlartMedical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, the Netherlands.
Daniel BermanDepartments of Medicine, Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Damini DeyDepartments of Medicine, Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Piotr SlomkaDepartments of Medicine, Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.
David E NewbyBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Marc R DweckBritish Heart Foundation Centre of Research Excellence, the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Funding
Patient-specific Outcome Prediction from Cardiovascular Multimodality Imaging by Artificial IntelligenceR35HL161195 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Piotr J Slomka · 2022 to 2026
$5.0MBritish Heart Foundation CH/09/002/26360British Heart Foundation CH/11/2/28733NHLBI NIH HHS R35 HL161195
Abstract
backgroundMyocardial fibrosis is a key healing response after myocardial infarction driven by activated fibroblasts. Gallium-68-labeled fibroblast activation protein inhibitor ([
objectivesThe aim of this study was to investigate the intensity, distribution, and time-course of fibroblast activation after acute myocardial infarction.
methodsA total of 40 patients with acute myocardial infarction underwent hybrid [
resultsMyocardial [
conclusionsMyocardial fibroblast activation peaks within a week of acute myocardial infarction and extends beyond the infarct region. It declines slowly with time, persists for years, and is associated with subsequent left ventricular remodeling. (PROFILE-MI-The FAPI Fibrosis Study; NCT05356923).
Indexed as
FibroblastsMagnetic Resonance ImagingMyocardial InfarctionMyocardiumPositron-Emission TomographyAgedFemaleFibrosisGallium RadioisotopesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedGallium Radioisotopesfibroblast activation protein inhibitormolecular PETmyocardial Infarction
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05356923ClinicalTrials.gov
NCT07657650ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.