ArticleCritical care medicine2025
An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome.
Article in Critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Whole blood resuscitation and post-traumatic organ dysfunction in injured children.Transfusion · 2026Observational
- ALM Resuscitation Without Transfusion Improves Platelet Function and Survival After Liver Injury and Uncontrolled Hemorrhage.Medicina (Kaunas, Lithuania) · 2026Article
- Whole blood resuscitation is associated with decreased end-organ dysfunction in pediatric trauma patients.The journal of trauma and acute care surgery · 2026Observational
- Eliminating leukocyte reduction for whole blood: Is it premature to consider this paradigm-changing practice?Transfusion · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo determine the association of whole blood and other blood products (components, prothrombin complex concentrate, and fibrinogen concentrate) with the development of acute respiratory distress syndrome (ARDS) among blood recipients.
designRetrospective cohort study.
settingAmerican College of Surgeons Trauma Quality Improvement Program (TQIP) database between 2020 and 2021. PATIENTS: Patients 15 years old or older in the TQIP database between 2020 and 2022 who received at least one blood product.
interventionsWe compared characteristics and blood product administration between patients who developed ARDS versus those who did not. MEASUREMENTS AND MAIN
resultsThere were 134,863 that met inclusion for this analysis. Within the included population, 1% (1927) was diagnosed with ARDS. The no ARDS group had a lower portion of serious injuries to the head/neck (31% vs. 46%), thorax (51% vs. 78%), abdomen (34% vs. 48%), and extremities (37% vs. 47%). The median composite Injury Severity Score was 21 (11-30) in the no ARDS group vs. 30 (22-41) in the ARDS group. Unadjusted survival of discharge was 74% in the no ARDS group vs. 61% in the ARDS group. In our multivariable model, we found that whole blood (unit odds ratio [uOR], 1.05; 95% CI, 1.02-1.07), male sex (odds ratio, 1.44; 95% CI, 1.28-1.63), arrival shock index (uOR, 1.03; 95% CI, 1.01-1.06), and composite Injury Severity Score (uOR, 1.03; 95% CI, 1.03-1.04) were associated with the development of ARDS. These persisted on sensitivity testing.
conclusionsWe found an association between whole blood and the development of ARDS among trauma patients who received blood transfusions. Contrary to previous studies, we found no association between ARDS and fresh frozen plasma administration. The literature would benefit from further investigation via prospective study designs.
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