Evidence map›Paper›PMID 39774777›Full record

Observational studyScientific reports2025

Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus.

Chen-Yu Lin, Yi-Jing Sheen, Hsian-Min Chen, Yi-An Lu, Jun-Peng Chen, Hsuan-En Huang, Yu-Ju Lin, Peng-Tai Tien, Chia-Jen Chang, Hui-Ju Lin and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chen-Yu LinDepartment of Ophthalmology, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Xitun Dist., Taichung, Taiwan. cylinscholar@gmail.com.
Yi-Jing SheenDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsian-Min ChenCenter for Quantitative Imaging in Medicine (CQUIM), Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-An LuDepartment of Ophthalmology, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Xitun Dist., Taichung, Taiwan.
Jun-Peng ChenBiostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan.
Hsuan-En HuangDepartment of Ophthalmology, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Xitun Dist., Taichung, Taiwan.
Yu-Ju LinDepartment of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Peng-Tai TienCollege of Medicine, National Chung Hsing University, Taichung, Taiwan.
Chia-Jen ChangDepartment of Ophthalmology, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Xitun Dist., Taichung, Taiwan.
Hui-Ju LinEye Center, China Medical University Hospital, Taichung, Taiwan.
I-Jong WangGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chien-Chih ChouDepartment of Ophthalmology, Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Blvd., Xitun Dist., Taichung, Taiwan. doctorccc@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as a marker for DR in diabetes mellitus (DM) patients. An observational study was conducted with 47 type 2 DM patients and 21 healthy controls. OCTA measured superficial and deep retinal VD in the parafoveal region. Statistical analyses, including logistic regression and ROC curve analysis, were used to assess the association between VD and DR presence. Results showed that DM patients had lower parafoveal superficial (46.73 vs. 52.37%, p = 0.002) and deep VD (50.35 vs. 54.26%, p = 0.019) compared to controls. Within the DM group, DR patients had lower VD in the superior parafoveal superficial layer (p = 0.042) and temporal parafoveal deep layer (p = 0.035). ROC analysis identified a cutoff of 51.86% for the temporal deep parafoveal VD, with an AUC of 0.697 (p = 0.035) and 81.8% sensitivity for DR discrimination. Reduced VD in the temporal deep parafoveal region is linked to a higher DR likelihood. OCTA-derived VD metrics offer promise for early DR detection and underscore the importance of monitoring vascular changes in DM patients.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathyFovea CentralisMicrocirculationTomography, Optical CoherenceAgedCase-Control StudiesFemaleHumansMaleMiddle AgedRetinal VesselsROC CurveDiabetic retinopathyOptical coherence tomography angiographyVessel density

Identifiers

PMID39774777
PMCPMC11707366

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.