Evidence map›Paper›PMID 39774838›Full record

ArticleCancer discovery2025

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.

Haoran Ma, Supriya Srivastava, Shamaine Wei Ting Ho, Chang Xu, Benedict Shi Xiang Lian, Xuewen Ong, Su Ting Tay, Taotao Sheng, Huey Yew Jeffrey Lum, Siti Aishah Binte Abdul Ghani and 22 more

Abstract read
In one paragraph

Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Trial
  2. Review
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  4. Review
  5. Immune niche composed of C1QNature communications · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Comprehensive genomics and functional analyses identifyTranslational cancer research · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. [Bottlenecks and breakthroughs in gastric cancer diagnosis and treatment: Towards a new era of precision and intelligent integration].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Haoran MaProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0004-9614-1832
Supriya SrivastavaDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6727-3076
Shamaine Wei Ting HoGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-2595-0710
Chang XuProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-5278-5063
Benedict Shi Xiang LianProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-3467-5394
Xuewen OngProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0000-4518-5166
Su Ting TayProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-3609-0143
Taotao ShengGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0003-3809-4885
Huey Yew Jeffrey LumDepartment of Pathology, National University Hospital, Singapore, Singapore.ORCID 0000-0002-3513-2404
Siti Aishah Binte Abdul GhaniProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-2317-0179
Yunqiang ChuCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6646-9739
Kie Kyon HuangProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-4104-8951
Yeek Teck GohGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0009-0003-0948-9631
Minghui LeeProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0005-3261-5178
Takeshi HagiharaProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0007-9263-1553
Clara Shi Ya NgProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0009-0000-2090-1955
Angie Lay Keng TanProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-8238-0515
Yanrong ZhangDepartment of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore, Singapore.ORCID 0009-0000-8018-8469
Zichen DingSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-9885-9221
Feng ZhuDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-6030-9251
Michelle Shu Wen NgGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0009-0002-5028-2272
Craig Ryan Cecil JosephInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0009-0004-5326-9692
Hui ChenMGI Tech Singapore Pte. Ltd., Singapore, Singapore.ORCID 0009-0004-9396-0023
Zhen LiMGI Tech Singapore Pte. Ltd., Singapore, Singapore.ORCID 0009-0002-0543-3377
Joseph J ZhaoYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2002-5390
Sun Young RhaYonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.ORCID 0000-0002-2512-4531
Ming TehDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-6879-8678
Joe YeongDepartment of Pathology, National University Hospital, Singapore, Singapore.ORCID 0000-0002-6674-7153
Wei Peng YongYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-4404-3777
Jimmy Bok-Yan SoYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-9772-7905
Raghav SundarProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-9423-1368
Patrick TanProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0002-0179-8048

Funding

Cancer Science Institute of Singapore, National University of Singapore (CSI)Duke-NUS Medical School (DukeNUS)Ministry of Health -Singapore (MOH) CIRG23Jul-0035Ministry of Health -Singapore (MOH) MOH-OFLCG18May-0003
6 · The paper itself

Abstract

significanceIntegration of spatial transcriptomic (GeoMx Digital Spatial Profiler) and single-cell RNA sequencing data from multiple gastric cancers identifies spatially resolved expression-based intratumoral heterogeneity, associated with distinct immune microenvironments. We uncovered two separate evolutionary trajectories associated with specific molecular subtypes, clinical prognoses, stromal neighborhoods, and genetic drivers. Tumor-stroma interfaces emerged as a unique state of tumor ecology.

Indexed as

AdenocarcinomaStomach NeoplasmsTumor MicroenvironmentDisease ProgressionHumansSingle-Cell Analysis

Identifiers

PMID39774838
PMCPMC11962405

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.