ArticleCommunications biology2025
Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Extraocular Electrical Stimulation Activates Retinal Ganglion Cells In Vivo.bioRxiv : the preprint server for biology · 2026Article
- Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Intracranial electrical kilohertz stimulation has recently been shown to achieve similar therapeutic benefit as conventional frequencies around 140 Hz. However, it is unknown how kilohertz stimulation influences neural activity in the mammalian brain. Using cellular calcium imaging in awake mice, we demonstrate that intracranial stimulation at 1 kHz evokes robust responses in many individual neurons, comparable to those induced by conventional 40 and 140 Hz stimulation in both the hippocampus and sensorimotor cortex. The evoked responses at the single-cell level are shaped by prominent network inhibition and critically depend on brain region. At the network level, all frequencies lead to pronounced population suppression except 1 kHz in the cortex, which evokes balanced excitatory and inhibitory population effects. Thus, kilohertz stimulation robustly modulates neural activity at both the single-neuron and population network levels through mechanisms distinct from conventional frequency stimulation, highlighting the clinical potential of intracranial kilohertz neuromodulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.