Review in Current obesity reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Alyssa HuangDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Dabin YeumDepartment of Medicine, University of Washington, Seattle, WA, USA.
Leticia E SewaybrickerDepartment of Medicine, University of Washington, Seattle, WA, USA.
Sandra AleksicDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Melbin ThomasDepartment of Medicine, University of Washington, Seattle, WA, USA.
Susan J MelhornDepartment of Medicine, University of Washington, Seattle, WA, USA.
Yumei Feng EarleyDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Ellen A SchurDepartment of Medicine, University of Washington, Seattle, WA, USA. ellschur@uw.edu.
Funding
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
A twin study of obesity pathogenesis using fMRIR01DK089036 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2011 to 2022
$6.2M
Brain systems and behaviors underlying response to obesity treatment in childrenR01DK098466 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI ROTH, CHRISTIAN LUDWIG · 2014 to 2023
$5.6M
TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI EARLEY, SCOTT, FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
Impact of hypothalamic gliosis on appetite regulation and obesity risk in childrenR01DK117623 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2019 to 2023
$3.7M
Physiological changes underlying the weight loss plateau in humansR01DK134417 · NIDDK · UNIVERSITY OF WASHINGTON · PI Marian L Neuhouser, Ellen A Schur · 2023 to 2026
$3.0M
Neural mechanisms regulating glucose homeostasisR01DK135621 · NIDDK · UNIVERSITY OF ROCHESTER · PI Yumei Feng Earley · 2023 to 2026
$2.2M
Neural and behavioral mechanisms of obesity development from infancy through childhoodR01DK136602 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Susan Carnell, Viren Andrew D'Sa · 2024 to 2026
$2.1M
Assessing the effect of diet on hypothalamic gliosis in humansR01DK133356 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2022 to 2024
$1.0M
Fostering patient-oriented research in cardiometabolic disease pathogenesis and preventionK24HL144917 · NHLBI · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 2019 to 2026
$965k
American Heart Association AHA#929228National Institute on Aging and American Federation for Aging Research 1K76AG083274NHLBI NIH HHS K24 HL144917NHLBI NIH HHS R01 HL122770NHLBI NIH HHS R35 HL155008NHLBI NIH HHS T32 HL007028NIA NIH HHS K76 AG083274NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK089036NIDDK NIH HHS R01 DK098466NIDDK NIH HHS R01 DK117623NIDDK NIH HHS R01 DK133356NIDDK NIH HHS R01 DK134417NIDDK NIH HHS R01 DK135621NIDDK NIH HHS R01 DK136602NIH HHS R01DK089036, R01DK117623, R01DK098466, R01DK134417, R01DK133356, K24HL144917, R01DK136602NIH HHS R01HL122770University of Washington Nutrition Obesity Research Center P30DK035816
6 · The paper itself
Abstract
purpose of reviewTo evaluate the role of hypothalamic inflammation and gliosis in human obesity pathogenesis and other disease processes influenced by obesity. RECENT
findingsRecent studies using established and novel magnetic resonance imaging (MRI) techniques to assess alterations in hypothalamic microarchitecture in humans support the presence of hypothalamic inflammation and gliosis in adults and children with obesity. Studies also identify prenatal exposure to maternal obesity or diabetes as a risk factor for hypothalamic inflammation and gliosis and increased obesity risk in offspring. Hypothalamic inflammation and gliosis have been further implicated in reproductive dysfunction (specifically polycystic ovarian syndrome and male hypogonadism), cardiovascular disease namely hypertension, and alterations in the gut microbiome, and may also accelerate neurocognitive aging. The most recent translational studies support the link between hypothalamic inflammation and gliosis and obesity pathogenesis in humans and expand our understanding of its influence on broader aspects of human health.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity. · full record | Socratic