Evidence map›Paper›PMID 39775393›Full record

SynthesisObesity surgery2025

Comparative Analysis of Renal Function Outcomes Following Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Systematic Review and Meta-analysis.

Rafaela Hamada Juca, Pedro Bicudo Bregion, Josélio Rodrigues de Oliveira-Filho, Giulia Almiron da Rocha Soares, Sofia Hamada Juca, Victor Kenzo Ivano, Everton Cazzo

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rafaela Hamada JucaState University of Campinas, Campinas, Brazil.
Pedro Bicudo BregionState University of Campinas, Campinas, Brazil.
Josélio Rodrigues de Oliveira-FilhoHospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil.
Giulia Almiron da Rocha SoaresUniversidade Metropolitana de Santos, Santos, Brazil.
Sofia Hamada JucaCentro Universitário de Votuporanga, Votuporanga, Brazil.
Victor Kenzo IvanoState University of Campinas, Campinas, Brazil.
Everton CazzoState University of Campinas, Campinas, Brazil. notrevezzo@yahoo.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a significant risk factor for chronic kidney disease (CKD), with metabolic bariatric surgery offering potential renal benefits. However, there is limited comparative data on the impact of Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG) on renal function in individuals with obesity without end-stage renal disease (ESRD). The objective of this study was to compare renal function outcomes following RYGB and LSG in patients with obesity, focusing on estimated glomerular filtration rate (eGFR), serum creatinine, albumin-creatinine ratio (ACR), and serum cystatin C.

methodsA systematic review and meta-analysis were conducted following Cochrane and PRISMA guidelines. Data from 17 observational studies (n = 3339) were analyzed. Primary outcomes included changes in eGFR, ACR, serum creatinine, and cystatin C. Secondary outcomes included excess weight loss (%EWL) and total weight loss (%TWL). Statistical analysis involved fixed and random-effects models based on heterogeneity levels.

resultsRYGB demonstrated significant improvements in eGFR (SMD =  - 0.71; 95% CI - 0.89 to - 0.52, p < 0.00001) and serum cystatin C (MD =  - 0.10; 95% CI - 0.17 to - 0.03, p = 0.004) compared to LSG. No significant differences were found for serum creatinine (MD =  - 1.06; 95% CI - 4.42 to 2.30, p = 0.54) or ACR (MD = 1.95; 95% CI - 0.39 to 4.29, p = 0.10). RYGB also showed greater long-term weight loss, particularly at 5 years (%EWL: MD = 22.00; 95% CI 6.56 to 37.44, p = 0.005).

conclusionsRYGB offers similar renal improvements with superior weight loss compared to LSG in individuals with obesity without ESRD. These findings emphasize the need for personalized treatment approaches and further research to validate these outcomes.

Indexed as

GastrectomyGastric BypassKidneyLaparoscopyObesity, MorbidRenal Insufficiency, ChronicCreatinineCystatin CGlomerular Filtration RateHumansTreatment OutcomeWeight LossCreatinineCystatin CBariatric surgeryGastrectomyGastric bypassObesityRenal function

Identifiers

PMID39775393

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.