Evidence map›Paper›PMID 39775452›Full record

ReviewLab on a chip2025

Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization.

Xuan Mei, Ziyi Yang, Xiran Wang, Alan Shi, Joel Blanchard, Fanny Elahi, Heemin Kang, Gorka Orive, Yu Shrike Zhang

Abstract readReview
In one paragraph

Review in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuan MeiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@bwh.harvard.edu.
Ziyi YangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@bwh.harvard.edu.
Xiran WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@bwh.harvard.edu.
Alan ShiBrookline High School, Brookline, MA 02445, USA.
Joel BlanchardDepartments of Neurology, Neuroscience, and Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Fanny ElahiDepartments of Neurology, Neuroscience, and Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Heemin KangDepartment of Materials Science and Engineering, Korea University, Seoul 02841, Republic of Korea. heeminkang@korea.ac.kr.ORCID 0000-0003-2694-9882
Gorka OriveNanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain. gorka.orive@ehu.eus.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@bwh.harvard.edu.ORCID 0000-0002-0045-0808

Funding

High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics ScreeningR01HL166522 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Junjie Yao, Y. Shrike Zhang · 2023 to 2026
$2.7M
Biomaterials for embolization and ablation of arterio-venous malformationsR01HL165176 · NHLBI · MAYO CLINIC ARIZONA · PI OKLU, RAHMI, ZHANG, Y. SHRIKE · 2022 to 2025
$2.6M
Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
"Clinical Trials" on a Premature Vascular Aging-on-a-Chip ModelUH3TR003274 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2022 to 2024
$1.8M
A Bioprinted Volumetric Model of Vascularized GlioblastomaR01CA282451 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Kaisorn Lee Chaichana, Y. Shrike Zhang · 2023 to 2026
$1.7M
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Development of An Optoelectronically Active BioinkR21EB030257 · NIBIB · UNIVERSITY OF HOUSTON · PI CHENG, HUANYU · 2020 to 2020
$694k
Cryobioprinting for Shelf-Ready Tissue Fabrication and StorageR56EB034702 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2023 to 2023
$499k
CSRD VA IK2 CX002180National Science Foundation CBET-EBMS-1936105National Science Foundation CISE-IIS-2225698NCATS NIH HHS UH3 TR003274NCI NIH HHS R01 CA282451NHLBI NIH HHS R01 HL153857NHLBI NIH HHS R01 HL165176NHLBI NIH HHS R01 HL166522NIBIB NIH HHS R21 EB025270NIBIB NIH HHS R21 EB030257NIBIB NIH HHS R56 EB034702
6 · The paper itself

Abstract

Tissue engineering offers immense potential for addressing the unmet needs in repairing tissue damage and organ failure. Vascularization, the development of intricate blood vessel networks, is crucial for the survival and functions of engineered tissues. Nevertheless, the persistent challenge of ensuring an ample nutrient supply within implanted tissues remains, primarily due to the inadequate formation of blood vessels. This issue underscores the vital role of the human vascular system in sustaining cellular functions, facilitating nutrient exchange, and removing metabolic waste products. In response to this challenge, new approaches have been explored. Microfluidic devices, emulating natural blood vessels, serve as valuable tools for investigating angiogenesis and allowing the formation of microvascular networks. In parallel, bioprinting technologies enable precise placement of cells and biomaterials, culminating in vascular structures that closely resemble the native vessels. To this end, the synergy of microfluidics and bioprinting has further opened up exciting possibilities in vascularization, encompassing innovations such as microfluidic bioprinting. These advancements hold great promise in regenerative medicine, facilitating the creation of functional tissues for applications ranging from transplantation to disease modeling and drug testing. This review explores the potentially transformative impact of microfluidic and bioprinting technologies on vascularization strategies within the scope of tissue engineering.

Indexed as

BioprintingLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesNeovascularization, PhysiologicTissue EngineeringAnimalsHumans

Identifiers

PMID39775452
PMCPMC12961684

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.