Evidence map›Paper›PMID 39775569›Full record

Trial reportJournal of clinical pharmacology2025

Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations.

Joseph E Rower, Michael D Johnson, Joseph J Zorc, Bashar Shihabuddin, Mengtao Dai, Bradley J Barney, Yaron Finkelstein

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph E RowerDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-3629-7902
Michael D JohnsonDivision of Emergency Medicine, Department of Pediatrics, University of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.
Joseph J ZorcDepartment of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Bashar ShihabuddinSection of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.
Mengtao DaiDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Bradley J BarneyDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Yaron FinkelsteinDivision of Emergency Medicine and Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada.

Funding

Utah Trial Innovation CenterU24TR001597 · NCATS · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2016 to 2022
$39.6M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED)R34HL152047 · NHLBI · UNIVERSITY OF UTAH · PI JOHNSON, MICHAEL DAVID, ZORC, JOSEPH J · 2022 to 2023
$738k
CHaMP node- State University of New York at Buffalo U03MC33154EMSC Data Center (EDC)-University of Utah UJ5MC30824GLACiER-Nationwide Children's Hospital U03MC28844HOMERUN-Cincinnati Children's Hospital Medical Center U03MC22684NCATS NIH HHS U24 TR001597NCATS NIH HHS U24TR001597NCATS NIH HHS UM1 TR004409NHLBI NIH HHS R34 HL152047NHLBI NIH HHS R34HL152047Pediatric Acute Care Applied Research Network (PECARN) R34HL152047PEMNEWS-Columbia University Medical Center U03MC00007PRIME-University of California at Davis Medical Center U03MC00001SPARC node - Emory University School of Medicine U03MC49671STELAR - Seattle Children's Hospital U03MC33156
6 · The paper itself

Abstract

Pediatric asthma exacerbations represent a significant cause of emergency department use and hospitalizations. Despite available treatment options, many children's exacerbations are refractory to standard therapies and require adjunct treatments. The Intravenous Magnesium: Prompt use for Asthma in Children Treated in the Emergency Department study investigated the pharmacology of intravenous magnesium sulfate (IVMg) in treating pediatric asthma exacerbations. Specifically, the objectives of the study included (1) externally validating a previously published population pharmacokinetic model and (2) linking serum magnesium concentrations with outcomes including asthma severity score (efficacy) and hypotension (safety). Data were obtained from 49 children prospectively treated with IVMg (placebo, 50 or 75 mg/kg) after presenting to the pediatric emergency department with an acute asthma exacerbation. Reductions in Pediatric Respiratory Assessment Measure scores were associated with both total and ionized serum magnesium area under the concentration-time curve (AUC

Indexed as

Anti-Asthmatic AgentsAsthmaMagnesium SulfateAdministration, IntravenousAdolescentChildChild, PreschoolDose-Response Relationship, DrugDouble-Blind MethodEmergency Service, HospitalFemaleHumansHypotensionMagnesiumMaleProspective StudiesAnti-Asthmatic AgentsMagnesiumMagnesium Sulfateblood pressuremagnesium sulfatepediatric asthmaPediatric Respiratory Assessment Measurepharmacodynamicspharmacokinetics

Identifiers

PMID39775569
PMCPMC12110724

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.