ArticleCancer discovery2025
Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.
Abstract read
In one paragraph
Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Tumour-associated dsRNA accumulation and innate immune activation: mechanistic basis and therapeutic strategies.EBioMedicine · 2026Review
- Phylogenetic and phylodynamic approaches to understanding the evolution of non-small cell lung cancer using single-cell sequencing.Oncogene · 2026Article
- Viral mimicry escape as a necessary feature of malignant transformation.Nature reviews. Cancer · 2026Review
- Mutant TP53 hijacks RNA-splicing factor RBM28 to suppress double-stranded RNA triggered antitumor immunity.Nature communications · 2026Article
- Transposable Element Activation: A Hallmark of Cancer.Cancer discovery · 2026Review
- Multilayer modeling reveals an endogenous retrovirus signature predictive of induction chemotherapy failure in AML.Blood neoplasia · 2026Article
- The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Multiomic profiling links L1 retrotransposition to genomic instability and ecDNA in bladder cancer.Nature communications · 2026Article
- Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium.Cancer research · 2026Article
- Review
- Rethinking ovarian cancer III: the past decade and future directions.Nature reviews. Cancer · 2026Review
- Expression of endogenous retroviral elements is associated with extracellular matrix remodeling in prostate cancer.Mobile DNA · 2026Article
- The impact of p53 mutation on tumor immune evasion: mechanistic insights and clinical implications.Frontiers in immunology · 2026Review
- Inducing tumor-intrinsic innate immune response to break cancer immunotherapy resistance.Frontiers in medicine · 2026Review
- Repeats mimic pathogen-associated patterns across a vast evolutionary landscape.Cell genomics · 2025Article
- Article
- Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations.bioRxiv : the preprint server for biology · 2025Article
- Loss ofOncotarget · 2025Article
- p53motifDB: integration of genomic information and tumour suppressor p53 binding motifs.Database : the journal of biological databases and curation · 2025Article
- Interplay of replication stress response and immune microenvironment in high-grade serous ovarian cancer.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors.
Charles A Ishak *Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-2287-6738
Sajid A Marhon *Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-1046-9852
Naïri Tchrakian *Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0003-2482-6416
Anjelica Hodgson *Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-4069-2000
Helen Loo Yau *Department of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0003-4867-8593
Isabela M GonzagaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-0342-877X
Melanie PeraltaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0009-0008-0409-3933
Ilinca M LunguDiagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.ORCID 0000-0002-9996-5771
Stephanie GomezDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0002-4494-659X
Sheng-Ben LiangPrincess Margaret Cancer Biobank, University Health Network, Toronto, Canada.ORCID 0000-0002-3251-8387
Shu Yi ShenPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0001-7036-2291
Raymond ChenDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0009-0006-8355-4333
Jocelyn ChenDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0002-7198-6386
Biji ChatterjeeDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-3854-8181
Kevin N WanniarachchiDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0009-0008-9903-7802
Junwoo LeeDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-5821-2274
Nicholas ZehrbachDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0009-0003-1315-3081
Amir HosseiniPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0001-8229-832X
Parinaz MehdipourPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-4476-9925
Siyu SunDepartment of Epidemiology and Biostatistics, Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-8461-9609
Alexander SolovyovDepartment of Epidemiology and Biostatistics, Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-7682-4706
Ilias EttayebiDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0001-5964-3666
Kyle E FrancisPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0001-6688-2251
Aobo HeDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0001-8609-0542
Taiyi WuDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0001-5084-6520
Shengrui FengDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.ORCID 0000-0002-5321-5529
Tiago da Silva MedinaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0001-8674-8842
Felipe Campos de AlmeidaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0003-0158-1102
Jane BayaniDiagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.ORCID 0000-0002-1699-5888
Jason LiDiagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.ORCID 0000-0002-9174-2514
Spencer MacDonaldPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-2115-6085
Yadong WangPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0009-0006-2096-0094
Sarah S GarciaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0009-0002-7409-4102
Elisa ArthoferDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0001-6487-4856
Noor DiabDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0003-1665-8125
Aneil SrivastavaDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0003-2414-2890
Paul Tran AustinDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0002-3652-6296
Peter J B SabatiniPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-3361-0468
Benjamin D GreenbaumDepartment of Epidemiology and Biostatistics, Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-6153-8793
Catherine A O'BrienPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0003-0682-3879
Trevor G ShepherdDepartment of Obstetrics and Gynaecology, Western University, London, Canada.ORCID 0000-0002-1853-8066
Ming Sound TsaoPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-9160-5405
Katherine B ChiappinelliDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.ORCID 0000-0001-9241-9105
Amit M OzaPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-9510-8641
Blaise A ClarkePrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-2585-8391
Robert RottapelPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-6024-5558
Stephanie LheureuxPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0003-4405-5890
Daniel D De CarvalhoPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-8572-5259
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MA Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor ImmunityU01CA228963 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GREENBAUM, BENJAMIN, TING, DAVID TSAI · 2020 to 2024
$3.2MEpigenetic activation of the interferon response to sensitize cancers to immune therapyR00CA204592 · NCI · GEORGE WASHINGTON UNIVERSITY · PI CHIAPPINELLI, KATHERINE B · 2017 to 2019
$747kThe Role of RNA Editing in the DNMTi-induced interferon response in ovarian cancerF31CA254315 · NCI · GEORGE WASHINGTON UNIVERSITY · PI GOMEZ, STEPHANIE · 2020 to 2022
$80kCanadian Institutes of Health Research (CIHR) 201512MSH-360794-228629Canadian Institutes of Health Research (CIHR) MFE-164724Canadian Institutes of Health Research (CIHR) PJT-165986National Cancer Institute (NCI) 1F31CA254315-01National Cancer Institute (NCI) R00CA204592NCI NIH HHS F31 CA254315NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA204592NCI NIH HHS U01 CA228963
Abstract
significanceOur landmark discovery of viral mimicry characterized repetitive elements as immunogenic stimuli that cull cancer cells. If expressed repetitive elements cull cancer cells, why does every human cancer express repetitive elements? Our report offers an exciting advancement toward understanding this paradox and how to exploit this mechanism for cancer interception. See related commentary by Murayama and Cañadas, p. 670.
Indexed as
Immune EvasionMolecular MimicryNeoplasmsTumor Suppressor Protein p53HumansTumor Suppressor Protein p53
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.