Evidence map›Paper›PMID 39776263›Full record

ArticleNeurosurgical review2025

Intracranial hemorrhagic events associated with flow diversion treatment: a retrospective analysis from a single academic institution.

Aryan Wadhwa, Felipe Ramirez-Velandia, Alejandro Enriquez-Marulanda, Jean Filo, Thomas B Fodor, Daniel Sconzo, Michael Young, Sandeep Muram, Justin H Granstein, Max Shutran and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aryan Wadhwa *Neurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Felipe Ramirez-Velandia *Neurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Alejandro Enriquez-MarulandaNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Jean FiloNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Thomas B FodorNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Daniel SconzoNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Michael YoungNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Sandeep MuramNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Justin H GransteinNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Max ShutranNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Philipp TausskyNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA.
Christopher S OgilvyNeurosurgical Service, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis Street, Boston, MA, 02215, USA. cogilvy@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial hemorrhages are highly concerning but underreported complications related to flow diversion (FD) treatment of intracranial aneurysms. Herein, we aimed to characterize these complications and the factors influencing their occurrence. We retrospectively reviewed patients treated with FD from 2013 to 2023 at a single U.S. institution, analyzing aneurysm characteristics, comorbidities, antiplatelet and anticoagulation use, and hemorrhage imaging features. Risk factors for intraparenchymal hemorrhages (IPHs) were assessed with univariate analysis. There were 622 patients harboring 788 aneurysms treated in 690 procedures during the study period. Within 7 months of follow-up, 15 intracranial hemorrhages were identified (2.2%): 2 acute subdural hematomas (SDH), 7 IPH, 1 intraventricular hemorrhage (IVH), and 5 subarachnoid hemorrhages (SAH), most of which presented within the first 24 h after initial treatment. Patients experiencing hemorrhages exhibited lower rates of functional independence (mRS ≤ 2) compared to those without hemorrhage (66.7% vs. 93.3%; p < 0.01). IPHs were slightly higher in patients receiving aspirin-ticagrelor (1.2%) compared to those on aspirin-clopidogrel (0.9%) or aspirin-prasugrel (0.0%). A univariate logistic regression model demonstrated an aneurysmal diameter ≥ 12 mm (OR = 8.98; 95% CI = 1.98-16.03) and aneurysms with prior treatment (OR = 7.20; 95% CI = 1.59-32.60) as factors influencing IPHs after treatment. The incidence of hemorrhage decreased over the time interval of study. Intracranial hemorrhages related to FD are rare but highly morbid complications. Treatments involving larger aneurysms and those with prior interventions are associated with a higher risk of IPHs.

Indexed as

Intracranial AneurysmIntracranial HemorrhagesNeurosurgical ProceduresAgedFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesDisabilityFlow diversionIntracranial aneurysmsIntracranial hemorrhageIntraparenchymal hemorrhageSubarachnoid hemorrhage

Identifiers

PMID39776263

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.