ArticleNeurocritical care2025
Impact of Microcirculatory Dysfunction on Persistent Global Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: An Age-Stratified Analysis.
Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Risk score for futile recanalization: integrating cerebral circulation time and collateral cascade.Frontiers in aging neuroscience · 2026Article
- The role of glymphatic system in brain injury after subarachnoid hemorrhage.Frontiers in immunology · 2026Review
- Letter to the Editor: Impact of Microcirculatory Dysfunction on Persistent Global Cerebral Edema After Aneurysmal Subarachnoid Hemorrhage: An Age-Stratified Analysis.Neurocritical care · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundMicrocirculatory dysfunction is one of the most important pathophysiology mechanisms of global cerebral edema (GCE) after aneurysmal subarachnoid hemorrhage (aSAH). Data regarding the impact of microcirculatory dysfunction on persistent GCE following aSAH are currently lacking. The aim of our study was to investigate whether microcirculatory dysfunction is correlated with persistent GCE in patients with aSAH across different age groups.
methodsThe study was conducted in Beijing Tiantan Hospital from October 2020 to July 2023. Patients with aSAH who underwent computed tomographic perfusion (CTP) within 24 h after ictus were enrolled prospectively. The difference value of arteriovenous peak time (DV), which serves as an indicator of microcirculatory impairment, was derived from the time-density curve of CTP. Persistent GCE was defined as selective sulcal volume ≤ 11.3 mL at both admission and 7 ± 1 days after ictus. Age-stratified multivariable analyses were applied to identify the association between microcirculatory dysfunction and persistent GCE.
resultsA total of 390 patients with aSAH were enrolled; the mean age was 56.5 ± 12.1 years old, and 245 (65.1%) patients were female. On multivariable analysis, prolonged DV was significantly associated with increased risk of persistent GCE after aSAH in patients older than 60 years (adjusted odds ratio 1.350, 95% confidence interval 1.025-1.778), whereas this similar independent association was not observed in patients younger than 60 years after adjusting for confounding factors (adjusted odds ratio 1.002, 95% confidence interval 0.817-1.229).
conclusionsAn age-dependent association between microcirculatory dysfunction and increased risk of persistent GCE following aSAH was found, which offers promising insight into future research to investigate tailored treatments across different ages.
Indexed as
Identifiers
39776342What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.