Evidence mapPaperPMID 39777024Full record

ArticleAnimal cells and systems2025

Protein hydrolysates from

Kristian Riolo, Gianluca Antonio Franco, Ylenia Marino, Annamaria Ferreri, Sabrina Oliva, Vincenzo Parrino, Domenico Savastano, Salvatore Cuzzocrea, Enrico Gugliandolo, Alessia Giannetto

Abstract read
In one paragraph

Article in Animal cells and systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Bergamot (Antioxidants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristian RioloDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Gianluca Antonio FrancoDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Ylenia MarinoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Annamaria FerreriDepartment of Theoretical and Applied Sciences, Università degli Studi eCampus, Italy.
Sabrina OlivaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Vincenzo ParrinoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Domenico SavastanoVia Eritrea, Progetto Hermetia, Gioia Tauro, Italy.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Enrico GugliandoloDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Alessia GiannettoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-5853-2881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insect protein hydrolysates (PH) are emerging as valuable compounds with biological activity. The aim of the present study was to assess the potential cytoprotective effects of PH from the Black Soldier Fly (BPH, in the range 0.1-0.5 mg/mL) against inflammatory conditions and oxidative stress in LPS-challenged L-929 cells. BPH was effective in inhibiting LPS-induced ROS and nitrite production and in reducing the protein and transcript levels of remarkable inflammatory markers, such as TNF-α, IL-6, IL-1α, and IL-1β, as determined by ELISA and/or qPCR. Moreover, the BPH antioxidant and anti-inflammatory activities rely on the induction of selected genes and proteins involved in the antioxidant response (i.e.

Indexed as

anti-inflammatory activityantioxidant activityHermetia illucensprotein hydrolysatesROS

Identifiers

PMID39777024
PMCPMC11703461

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.