Evidence map›Paper›PMID 39777492›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Is there an association between birth characteristics and fractures in young adults? The HUNT Study, Norway.

Hilde Thomasli Holltrø, T I L Nilsen, B Schei, I Tronstad, J Horn, K Holvik, A K N Daltveit, E M Dennison, N C Harvey, A Langhammer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hilde Thomasli HolltrøDepartment of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. Hilde.t.holltro@ntnu.no.ORCID http://orcid.org/0009-0005-7317-2377
T I L NilsenDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
B ScheiDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
I TronstadHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
J HornHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
K HolvikDepartment of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
A K N DaltveitDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
E M DennisonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
N C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
A LanghammerHUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
M HoffDepartment of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Funding

Medical Research Council MC_PC_21003Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/2Norske Kvinners Sanitetsforening 40027)
6 · The paper itself

Abstract

This population study investigated the association between birth characteristics and fracture risk in 11,099 young adults (aged 19-54 years). Our findings indicate that birth weight, gestational age, and birth weight for gestational age were not associated with fractures in the wrist, humerus, hip, and spine in this population. PURPOSE: Skeletal development starts during fetal life, and it is estimated that most bone formation occurs in the 3rd trimester. This study examined the association between birth characteristics and fractures of the wrist, humerus, hip, and spine, in young adults (19-54 years).

methods11.099 participants in the 3

resultsDuring a median follow-up of 14.0 years (153,657 person-years), 290 fractures occurred. Mean age at first fracture was 41.4 years (SD 7.4). Overall, there were no clear associations between birth characteristics and fractures in these data. HR for fracture was 0.43 (0.15-1.24) for those with a birth weight < 2.5 kg (reference birth weight 3.5 - 3.9 kg); 1.04 (0.74 - 1.46) for those born small for gestational age (< 10th percentile, reference 10 - 90

conclusionBirth weight, gestational age, or birth weight for gestational age was not associated with an increased risk of fractures of the wrist, humerus, hip, and spine in young adults.

Indexed as

Birth WeightFractures, BoneOsteoporotic FracturesAdultFemaleGestational AgeHip FracturesHumansHumeral FracturesInfant, NewbornMaleMiddle AgedNorwayRisk FactorsSpinal FracturesWrist InjuriesBirth weightFracturePrematureYoung adults

Identifiers

PMID39777492
PMCPMC11882708

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.