Evidence map›Paper›PMID 39777496›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Transcriptionally downregulated GABAergic genes associated with synaptic density network dysfunction in temporal lobe epilepsy.

Rong Li, Ling Xiao, Honghao Han, Hongyu Long, Wei Liao, Zhenzhe Yang, Haoyue Zhu, Xuyang Wang, Ting Zou, Yongwen Huang and 10 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rong Li *The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.ORCID 0000-0001-7266-0241
Ling Xiao *Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.ORCID 0000-0001-9808-4000
Honghao Han *The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.ORCID 0009-0001-0236-2254
Hongyu LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.
Wei LiaoThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Zhenzhe YangThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Haoyue ZhuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.
Xuyang WangThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Ting ZouThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Yongwen HuangThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Bharat B BiswalThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Ming ZhouDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.
Jian LiDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.
Yulai LiDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Huafu ChenThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China. chenhf@uestc.edu.cn.
Yongxiang TangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China. 405035@csu.edu.cn.ORCID 0000-0003-3987-8702
Li FengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China. fenglihx@163.com.ORCID 0000-0001-7658-1399
Shuo HuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, P.R. China. hushuo2018@163.com.ORCID 0000-0003-0998-8943

Funding

China Postdoctoral Science Foundation 2022M723561Clinical Research Foundation of the National Clinical Research Center for Geriatric Diseases 2023LNJJ16National Key Clinical Specialty Discipline Construction Program of China Z2023004National Natural Science Foundation of China 62333003National Natural Science Foundation of China 81801740National Natural Science Foundation of China 82071461National Natural Science Foundation of China 82072006National Natural Science Foundation of China 82271503Science and Technology Innovation Program of Hunan Province 2021RC4056Science Fund for Distinguished Young Scholars of Hunan Province 2024JJ2094Sichuan Science and Technology Foundation 2023NSFSC0644
6 · The paper itself

Abstract

purposeTemporal lobe epilepsy (TLE) is a brain network disorder closely associated with synaptic loss and has a genetic basis. However, the in vivo whole-brain synaptic changes at the network-level and the underlying gene expression patterns in patients with TLE remain unclear.

methodsIn this study, we utilized a positron emission tomography with the synaptic vesicle glycoprotein 2 A radioligand [

resultsWe observed an overall decrease in strength, reduced clustering coefficient, and increased path length of SDSN in TLE, suggesting a loss of connectivity that is accompanied by network reorganization. These changes were predominantly distributed in the temporo-limbic circuit and fronto-parietal networks. Moreover, connectivity changes in SDSN were found to be spatially correlated with the brain-wide expression of TLE risk genes, and the transcriptional correlate of SDSN changes showed a significant relationship with gene dysregulation. In particular, we identified a total of 183 downregulated genes that were functionally enriched for synaptic transmission pathways, forming a highly connected genetic interaction network. Within this set of genes, GABAergic genes such as RBFOX1 play a central role. DISCUSSION: Our study provides the first evidence that the spatial expression patterns of downregulated risk genes underlie in vivo synaptic density network dysfunction in TLE. These imaging-transcriptomic findings have the potential to guide the development of molecular and genetic network-based therapeutic approaches for TLE.

Indexed as

Down-RegulationEpilepsy, Temporal LobeSynapsesAdultFemaleGene Regulatory NetworksHumansMaleMiddle AgedPositron-Emission TomographyGABAergic inhibitionGene expressionSV2A PETSynaptic density networkTemporal lobe epilepsy

Identifiers

PMID39777496

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.