Evidence map›Paper›PMID 39777717›Full record

ArticleIndian journal of pediatrics2026

Impact of Omega-3 Enriched Lipid Emulsions on Retinopathy of Prematurity in Very Low Birth Weight Infants: A Retrospective Cohort Analysis.

Xing Li, Jiami Lin, Hongxia Zhou, Hai-Feng Lv, Lili Yang, Zhou Jiang

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Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing Li *Department of Pharmacy, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China.ORCID 0000-0002-2251-1982
Jiami Lin *Department of Nursing, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China.
Hongxia ZhouDepartment of Geriatric Psychiatry, Taizhou Second People's Hospital, Taizhou, 317200, China.
Hai-Feng LvSchool of Pharmacy, Hangzhou Medical College, Hangzhou, 310053, China.
Lili YangDepartment of Nursing, Qiantang Campus, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China. 3200006@zju.edu.cn.
Zhou JiangDepartment of Neonatal Intensive Care Unit, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310018, China. 5200013@zju.edu.cn.

Funding

Hangzhou Medical and Health Technology Project A20230723
6 · The paper itself

Abstract

objectivesTo assess the effects of ω-3 long-chain polyunsaturated fatty acid (LCPUFA)-enriched lipid emulsions (SMOFlipid) vs. traditional soybean oil-based lipid emulsions (Intralipid) on the occurrence and severity of retinopathy of prematurity (ROP) in infants with very low birth weight (VLBW).

methodsIn this retrospective cohort study, 301 VLBW infants who received either SMOFlipid or Intralipid for a minimum of 14 d were included. The main outcome measured was the frequency and severity of ROP, with secondary outcomes covering other complications associated with preterm birth.

resultsOf the infants studied, 180 were administered SMOFlipid, while 121 received Intralipid. The incidence of ROP was notably lower in the SMOFlipid group (32.8% vs. 45.5%; RR 0.59; 95% CI 0.36-0.94; P = 0.026). Additionally, the occurrence of severe ROP was reduced by 66.06% in infants given SMOFlipid (5.6% vs. 16.5%; RR 0.30; 95% CI 0.13-0.66; P = 0.002). Multivariate logistic regression suggested that using SMOFlipid was linked to a reduced risk of both ROP (OR 0.44; 95% CI 0.24-0.82; P = 0.010) and severe ROP (OR 0.09; 95% CI 0.03-0.30; P < 0.001). There were no considerable differences noted in other complications associated with preterm birth between the two groups.

conclusionsCompared to Intralipid, SMOFlipid treatment reduced both the risk and severity of ROP. Parenteral supplementation with fish oil-containing emulsions might offer a novel approach to lowering the incidence and severity of ROP in VLBW infants.

Indexed as

Fat Emulsions, IntravenousFatty Acids, Omega-3Infant, Very Low Birth WeightPhospholipidsRetinopathy of PrematuritySoybean OilEmulsionsFemaleFish OilsHumansIncidenceInfant, NewbornInfant, PrematureMaleOlive OilRetrospective StudiesEmulsionsFat Emulsions, IntravenousFatty Acids, Omega-3Fish OilsOlive OilPhospholipidsSMOFlipidSoybean Oilsoybean oil, phospholipid emulsionTriglyceridesLipid emulsionsParenteral nutritionRetinopathy of prematurityVLBW infants

Identifiers

PMID39777717

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.