Evidence map›Paper›PMID 39779056›Full record

ArticleJournal of the American College of Cardiology2025

Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure.

Jeffrey J Rade, Shari S Kronsberg, Thomas S Kickler, Ramachandran S Vasan, Vanessa Xanthakis, Matthew G Nayor, Bruce A Barton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey J RadeDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: jeffrey.rade@umassmed.edu.
Shari S KronsbergDivision of Biostatistics and Health Services Research, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Thomas S KicklerDepartment of Pathology, the Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Ramachandran S VasanDepartment of Quantitative and Qualitative Health Sciences, University of Texas School of Public Health in San Antonio, San Antonio, Texas, USA; Section of Preventative Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Vanessa XanthakisSection of Preventative Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Matthew G NayorSection of Preventative Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA; Section of Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Bruce A BartonDivision of Biostatistics and Health Services Research, Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195
6 · The paper itself

Abstract

backgroundSystemic thromboxane A

objectivesThis study sought to determine the association of urinary TXB

methodsUrine TXB

resultsHF occurred in 189 participants (7.2%), with 104 of the first events (55.0%) classified as HF with preserved LVEF, 56 (29.6%) as HF with reduced LVEF, and 29 (15.3%) were unclassifiable. TXB

conclusionsSystemic thromboxane A

Indexed as

Heart FailureThromboxane B2AgedAspirinBiomarkersFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsStroke VolumeAspirinBiomarkersThromboxane B2aspirinheart failureplateletsthromboxane

Identifiers

PMID39779056
PMCPMC12231177

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.