ArticleSaudi medical journal2025
Ajwa date extract (
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Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Nutraceuticals ofDrug design, development and therapy · 2026Review
- Phytochemical Analysis, In Vitro and In Vivo Evaluation of Ficus altissima Extract-Based Ointment and Hydrogel on Wound Healing.BioMed research international · 2026Article
- Antidiabetic Potential of Sea UrchinCurrent issues in molecular biology · 2025Article
- Biodiversity to Breakthroughs: The Promise of Saudi Arabian Medicinal Plants in Antiviral Research.Applied biochemistry and biotechnology · 2025Review
- Review
- Mechanistic Perspectives on Herpes Simplex Virus Inhibition by Phenolic Acids and Tannins: Interference with the Herpesvirus Life Cycle.International journal of molecular sciences · 2025Review
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Authors and funding
14 authors.
Ahmad K AljohaniFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.ORCID https://orcid.org/0000-0003-2332-1125
Nader A MaghrabiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Osama M AlrehiliFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Abdulaziz S AlharbiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Rawad S AlsihliFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Abdulrahman M AlhartheFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Rayan S AlbladiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Khalid A AlosaimiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Bader M AlbadraniFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Samar F MiskiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Hossein M ElbadawyFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Bandar D AlrehailiFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Fahd A AbdelkaremFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Modather F HusseinFrom the Department of Pharmacognosy and Pharmaceutical Chemistry (Aljohani), College of Pharmacy; from the College of Pharmacy (Maghrabi, Alrehili, Alharbi, Alsihli, Alharthe, Albladi, Alosaimi, Albadrani); from the Department of Pharmacology and Toxicology (Miski, Elbadawy, Alrehaili), College of Pharmacy, Taibah University, Al-Medinah Al-Munawarah, from the Departmet of Chemistry (Hussein), Collage of Science, Jouf University, Aljouf, Kingdom of Saudi Arabia; from the Graduate School of Bioresource and Bioenvironmental Science (Abdelkarem), Kyushu University, Kyushu, Japan; from the Department of Pharmacognosy (Abdelkarem), Faculty of Pharmacy; and from the Department of Chemistry (Hussein), Faculty of Science, Al-Azhar University, Assiut, Egypt.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action.
methodsHigh perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical profile of Ajwa date extract. The antiviral activity was assessed using the MTT colorimetric assay against herpes simplex virus type I (HSV-I) and coxsackievirus B4 (CVB-4). Assessment of the mechanism of action against HSV-I was carried out using 3 protocols. Molecular docking and quantum chemical calculations were carried out to predict the binding affinities of the identified compounds to viral glycoprotein D.
resultsA total of 17 metabolites belonging to different classes of metabolites, mainly flavonoids, phenolic acid derivatives, fatty acids, and sugar derivatives. Ajwa extract exhibited antiviral activity against HSV-I with an IC: 50 of 113.99±4.67 μg/mL, whereas it showed limited activity against CVB-4. The antiviral activity of Ajwa extract was mainly attributed to its cell protectant activity by preventing adherence of viral to host cell with an IC: 50 equal to 57.82±1.37μg/mL. Molecular docking studies indicated that chlorogenic acid had the strongest binding affinity to viral glycoprotein D, which suggests its potential role in inhibiting viral entry into host cells.
conclusionThe Ajwa date extract demonstrated promising antiviral activity, especially against HSV-I. Integrating in vitro and in silico analyses provided valuable insights into the mechanisms of action.
Indexed as
Antiviral AgentsEnterovirus B, HumanHerpesvirus 1, HumanMolecular Docking SimulationPhoeniceaePlant ExtractsAnimalsComputer SimulationHumansPhytochemicalsVero CellsAntiviral AgentsPhytochemicalsPlant ExtractsAjwa datesantiviral activitygas chromatography-mass spectrometryhigh-performance liquid chromatographymolecular docking
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LicenceCC BY-NC
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