Evidence map›Paper›PMID 39779566›Full record

ArticleCurrent pharmaceutical design2025

Bioactive Secondary Metabolites from

Yousaf Kamal, Nighat Fatima, Amara Mumtaz, Irum Shahzadi, Abdul Mannan, Gerardo D Anaya-Eugenio, Eric Daniel Salinas Arellano, Madiha Ahmed, Zahid Hussain, Esperanza J Carcache de Blanco

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Article in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yousaf KamalDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Nighat FatimaDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Amara MumtazDepartment of Chemistry, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Irum ShahzadiDepartment of Biotechnology, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Abdul MannanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad 22060, Pakistan.
Gerardo D Anaya-EugenioDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Eric Daniel Salinas ArellanoDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Madiha AhmedShifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad 44000, Pakistan.
Zahid HussainDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus 22060, Pakistan.
Esperanza J Carcache de BlancoDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aims to isolate and characterize potential cytotoxic compounds from the roots of

methodsThe root extracts were prepared using aqueous and organic solvents, including n-hexane, ethyl acetate, and methanol. The isolated compounds were subjected to a sulforhodamine B cytotoxicity assay against DU-145 and PC-3 (prostate), HT-29 (colon), and MCF-7 (breast) human cancer cell lines. Among the isolates, compound 5 exhibited significant bioactivity against all tested cell lines. Compound 4 demonstrated

resultsImportantly, these compounds were identified for the first time from

conclusionThe identification and characterization of these bioactive compounds contribute to the understanding of the potential therapeutic applications of B. variegata in cancer treatment.

Indexed as

Antineoplastic Agents, PhytogenicBauhiniaPlant ExtractsPlant RootsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureAntineoplastic Agents, PhytogenicPlant ExtractsBauhinia variegatacaesalpiniaceae.cytotoxic compoundshuman cancer cell linessulforhodamine B assaytherapeutic applications

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.