Evidence map›Paper›PMID 39779871›Full record

ArticleNature immunology2025

A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells.

Feifei Song, Ourania Tsahouridis, Simone Stucchi, Tara Walhart, Sophie Mendell, P Brian Hardy, Matthew Axtman, Shiva K R Guduru, Thomas S K Gilbert, Lee M Graves and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Feifei SongLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8866-1270
Ourania TsahouridisLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0621-6753
Simone StucchiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tara WalhartLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sophie MendellLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
P Brian HardyCenter for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Matthew AxtmanCenter for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shiva K R GuduruCenter for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thomas S K GilbertDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lee M GravesCenter for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Laura E HerringMichael Hooker Proteomics Center, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4496-7312
Barbara SavoldoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xingcong MaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mark WoodcockLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-7348-4980
Justin J MilnerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-0752-2130
Anastasia IvanovaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kenneth H PearceCenter for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-8138-5421
Yang XuLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. xuy6@sustech.edu.cn.ORCID http://orcid.org/0000-0003-1468-2703
Gianpietro DottiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gdotti@med.unc.edu.ORCID http://orcid.org/0000-0002-2639-8526

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Targeting B7-H3 in ovarian cancerR01CA256898 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Gianpietro Dotti, Linda Van Le · 2021 to 2026
$3.1M
Targeting the Ig-light chains with CAR-T cells in lymphoid tumorsR01CA193140 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOTTI, GIANPIETRO · 2016 to 2020
$2.7M
Tuning CAR-T cell functionR01CA247436 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOTTI, GIANPIETRO · 2021 to 2025
$2.4M
Cellular Immunotherapy of Ovarian CancerR01CA243543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOTTI, GIANPIETRO · 2019 to 2023
$2.0M
National Cancer Center R01CA193140National Cancer Center R01CA243543National Cancer Center R01CA247436National Cancer Center R01CA256898NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA193140NCI NIH HHS R01 CA243543NCI NIH HHS R01 CA247436NCI NIH HHS R01 CA256898
6 · The paper itself

Abstract

Chimeric antigen receptor T cells (CAR T cells) with T stem (T

Indexed as

Immunotherapy, AdoptiveNeoplasmsProtein Kinase InhibitorsReceptors, Chimeric AntigenStem CellsT-LymphocytesAnimalsCell Line, TumorHigh-Throughput Screening AssaysHumansLymphocyte ActivationMiceReceptors, Antigen, T-CellXenograft Model Antitumor AssaysProtein Kinase InhibitorsReceptors, Antigen, T-CellReceptors, Chimeric Antigen

Identifiers

PMID39779871
PMCPMC11785528

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.