Evidence map›Paper›PMID 39780017›Full record

ArticleNature2025

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Max L Valenstein, Pranav V Lalgudi, Jibril F Kedir, Kendall J Condon, Anna Platzek, Daniel G Freund, Martin S Taylor, Yunhan Xu, Raghu R Chivukula, David M Sabatini

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Max L Valenstein *Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mlvalenstein@mgb.org.ORCID http://orcid.org/0000-0001-7616-0148
Pranav V Lalgudi *Whitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1653-2338
Jibril F KedirWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1565-9049
Kendall J CondonWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Anna PlatzekWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Daniel G FreundWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Martin S TaylorHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1560-9276
Yunhan XuCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Raghu R ChivukulaDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
David M SabatiniInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-1446-7256

Funding

Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.K08DK129824 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TAYLOR, MARTIN S · 2021 to 2025
$853k
NIDDK NIH HHS K08 DK129824
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39780017

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.