ArticleBMC psychiatry2025
Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005-2018.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- The U-shaped correlation between the systemic immune-inflammation index and all-cause and cardiovascular mortality in hyperlipidemic patients: findings from NHANES 1999-2018.Annals of medicine · 2026Article
- Smoking and depressive symptoms: the mediating role of systemic inflammation in a US nationally representative sample.Annals of general psychiatry · 2026Article
- Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study.World journal of psychiatry · 2025Article
- The Role of Neuroinflammation in the Comorbidity of Psychiatric Disorders and Internal Diseases.Healthcare (Basel, Switzerland) · 2025Review
- Associations between internal exposure to acrylamide and sleep health: evidence from NHANES 2013-2016.BMC public health · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain.
methodsThis study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC analysis, subgroup and sensitivity analyses were also used.
resultsA total of 2442 adults with depression were included in the final analysis(average age: 46.51 ± 0.44 years). During a median follow-up of 89 months, there were 302 all-cause deaths and 74 cardiovascular deaths. The fully adjusted model showed that an increment of 100 unit in SII corresponded to an increased HR of 1.05(95% CI,1.02,1.08, p = 0.003) for all-cause mortality and 1.06(95% CI,1.02,1.10, p = 0.004) for cardiovascular mortality, respectively. The RCS analysis indicated a J-shape relationship between SII and all-cause mortality and a positive linear association between SII and cardiovascular mortality.The time-dependent ROC analysis exhibited excellent efficacy in SII for predicting all-cause and cardiovascular mortality at 1, 3, 5 and 10 years.
conclusionsHigher SII levels were associated with increased risk of all-cause and cardiovascular mortality in adults with depression. CLINICAL TRIAL NUMBER: Not applicable.
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