Evidence map›Paper›PMID 39780359›Full record

ArticlePhytochemical analysis : PCA2025

Isolation of a Unique Monoterpene Diperoxy Dimer From Ziziphora clinopodioides subsp. bungeana Together With Triterpenes With Antidiabetic Properties.

Milan Malaník, Jakub Treml, Renata Kubínová, Gabriela Vávrová, Michal Oravec, Jaromír Marek, Karlygash Zhaparkulova, Liliya Ibragimova, Tolkyn Bekezhanova, Aigerim Karaubayeva and 2 more

Abstract read
In one paragraph

Article in Phytochemical analysis : PCA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Investigating the Chemical-Biological Link inFood science & nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Milan MalaníkDepartment of Natural Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.ORCID https://orcid.org/0000-0001-8700-8416
Jakub TremlDepartment of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.ORCID https://orcid.org/0000-0002-8690-9981
Renata KubínováDepartment of Natural Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
Gabriela VávrováDepartment of Natural Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
Michal OravecGlobal Change Research Institute of the Czech Academy of Sciences, Brno, Czech Republic.
Jaromír MarekCore Facility Biomolecular Interactions and Crystallography, CEITEC MU, Masaryk University, Brno, Czech Republic.
Karlygash ZhaparkulovaSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Liliya IbragimovaSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.ORCID https://orcid.org/0000-0002-8381-5330
Tolkyn BekezhanovaSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Aigerim KaraubayevaSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Zuriyadda SakipovaSchool of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Karel ŠmejkalDepartment of Natural Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.

Funding

European Regional Development Fund-Project CZ.02.1.01/0.0/0.0/18_046/0015974Grantová Agentura České Republiky GAČR 23-04655SMinistry of Education, Youth, and Sports of the CR LM2023042Ministry of Education, Youth, and Sports of the CR LM2023048Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP23487559
6 · The paper itself

Abstract

introductionZiziphora clinopodioides subsp. bungeana (Juz.) Rech.f. is used in traditional medicine for various purposes. Previous phytochemical studies focused on phenolic compounds, but triterpenoids were almost overlooked.

objectiveThe study focused on the isolation of compounds with dual antidiabetic activity from the aerial parts of Z. clinopodioides subsp. bungeana. MATERIALS AND

methodsSeparation of CHCl

resultsThis phytochemical study led to the isolation of 20 compounds, including a unique monoterpene diperoxy dimer (1). Compounds 7 and 9-11 displayed more potent α-glucosidase inhibitory activity (IC

conclusionExtensive chromatographic separation led to the isolation and identification of a unique monoterpene diperoxy dimer (1) from aerial parts of Z. clinopodioides subsp. bungeana. Some triterpenes inhibited α-glucosidase, another increased GLUT4 translocation. Although none of the isolated compounds demonstrated dual antidiabetic activity, selected triterpenes proved to be potent antidiabetic agents in vitro.

Indexed as

Hypoglycemic AgentsLamiaceaeTriterpenesalpha-GlucosidasesAnimalsCell LineGlucose Transporter Type 4Glycoside Hydrolase InhibitorsMicePlant Components, AerialPlant Extractsalpha-GlucosidasesGlucose Transporter Type 4Glycoside Hydrolase InhibitorsHypoglycemic AgentsPlant ExtractsTriterpenesantidiabeticGLUT4pomolic acidtriterpenesZiziphoraα‐glucosidase

Identifiers

PMID39780359
PMCPMC12129716

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.