ArticleThe Journal of dermatology2025
Association of statins, gliptins, and antipsychotics with bullous pemphigoid: A case-control study in the Cretan population.
Article in The Journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of statins, gliptins, and antipsychotics with bullous pemphigoid: A case-control study in the Cretan population.The Journal of dermatology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bullous pemphigoid (BP) is an autoimmune blistering disorder predominantly affecting the elderly. Recently, many studies have shed light on the effect of specific drug intake and comorbidities on the development of BP. The purpose of this study was to investigate the association of specific drug class intake and comorbidities with the development of BP in the Cretan population. Significant associations with BP were found for statins (odds ratio [OR] = 4.06, 95% confidence interval [CI] 1.99-8.27, P < 0.001), gliptins (OR = 4.27, 95% CI 2.33-7.83, P < 0.001), and antipsychotics (OR = 3.33, 95% CI 1.36-8.11, P = 0.006). Higher proportions of use in the BP group vs. control group were found for atorvastatin (OR = 1.86, 95% CI 1.04-3.32, P = 0.035), linagliptin (OR = 6.63, 95% CI 2.17-20.23, P < 0.001), vildagliptin (OR = 3.20, 95% CI 1.73-5.91, P < 0.001), alogliptin (OR = 5.11, 95% CI 1.19-22.04, P = 0.016), and quetiapine (OR = 4.21, 95% CI 1.5-11.85, P = 0.004). The presence of diabetes mellitus in the absence of gliptins did not show any significant effect on BP (OR = 1.60, 95% CI 0.79-3.23, P = 0.188). Metformin intake showed no significant association with BP (OR = 0.48, 95% CI 0.18-1.28, P = 0.143). Our findings confirm and extend previous studies reporting the association of gliptins and antipsychotics on BP in other European populations. The association found for statins is new, thus more studies are needed to corroborate its validity.
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Registered trials
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