Evidence mapPaperPMID 39780700Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2025

The Impact of Dating Twin Pregnancy by the Larger, Smaller or Mean Twin Crown-Rump Length: A Retrospective Cohort Study.

Gillian V Blayney, Veronica Giorgione, Amar Bhide, Basky Thilaganathan

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Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gillian V BlayneyFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Veronica GiorgioneFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Amar BhideFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0003-2393-7501
Basky ThilaganathanFetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-5531-4301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the impact of twin dating by ultrasound-measured crown-rump length (CRL) of the larger (CRL-L), smaller (CRL-S) or mean twin measurement (CRL-M) on the rates of preterm birth (PTB) and detection of small for gestational age (SGA) births.

designA retrospective cohort study.

settingA tertiary fetal medicine centre (London, UK). POPULATION OR SAMPLE: All twin pregnancies between 1998 and 2023 who underwent first trimester CRL ultrasound assessment and fetal growth assessment.

methodsData collection included CRL measurement, estimated fetal weight (EFW), pregnancy outcome and birthweight (BW) for each twin. Pregnancies were retrospectively re-dated by CRL-S, CRL-L and CRL-M.

main outcome measuresSGA < 10th centile and extreme PTB rates (< 28 weeks).

resultsIn the 1129 twin pregnancies, median CRL-S was 61 mm (interquartile range [IQR]: 56.0-66.0) and CRL-L was 63 mm (IQR: 58.4-68.9) with a mean discordance of 4.0%. Prenatal SGA diagnosis occurred in 19.8% and 23.1% of smaller twins when dated by CRL-S and CRL-L, respectively. When pregnancies were dated by CRL-M versus CRL-S or CRL-L, there was no difference in prenatal SGA diagnosis (p = 0.275 and p = 0.419); SGA at birth (p = 0.132 and p = 0.325); or extreme PTB (p = > 0.999 and p = 0.765 respectively).

conclusionsDating by the smaller, larger or mean twin CRL does not significantly alter rates of extreme preterm birth, SGA detection or SGA birth. Dating by the mean twin CRL reduces stigmatisation of the smaller twin and retains the utility of accurate gestational age assessment without impacting clinical outcomes.

Indexed as

Crown-Rump LengthFetal Growth RetardationInfant, Small for Gestational AgePregnancy, TwinPremature BirthUltrasonography, PrenatalAdultBirth WeightFemaleGestational AgeHumansInfant, NewbornPregnancyPregnancy OutcomePregnancy Trimester, FirstRetrospective Studiescrown‐rump lengthgestational ageperinatal mortalitypregnancy datingpreterm birthsmall for gestational agetwins

Identifiers

PMID39780700
PMCPMC11879912

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.