Evidence map›Paper›PMID 39781453›Full record

ArticleInternational journal of biological sciences2025

TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function.

Melanie Tran, Baihai Jiao, Hao Du, Dong Zhou, Vijay Yechoor, Yanlin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melanie TranDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Baihai JiaoDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Hao DuDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Dong ZhouDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
Vijay YechoorDepartment of Medicine, University of Pittsburg, Pittsburg, PA, USA.
Yanlin WangDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.

Funding

Cellular and Molecular Mechanisms of Renal FibrosisR01DK095835 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, YANLIN · 2012 to 2021
$3.2M
Novel mechanisms of kidney inflammation and fibrosisR01DK134475 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YANLIN WANG · 2023 to 2026
$2.1M
BLRD VA I01 BX002650NIDDK NIH HHS R01 DK095835NIDDK NIH HHS R01 DK134475
6 · The paper itself

Abstract

Cisplatin is widely used for the treatment of solid tumors and its antitumor effects are well established. However, a known complication of cisplatin administration is acute kidney injury (AKI). In this study, we examined the role of TEA domain family member 1 (TEAD1) in the pathogenesis of cisplatin-induced AKI. TEAD1 expression was upregulated in tubular epithelial cells of kidneys with cisplatin-induced AKI. TEAD1 floxed mice (TEAD1

Indexed as

Acute Kidney InjuryCisplatinDNA-Binding ProteinsInflammationMitochondriaNecroptosisTEA Domain Transcription FactorsTranscription FactorsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReactive Oxygen SpeciesCisplatinDNA-Binding ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReactive Oxygen SpeciesTead1 protein, mouseTEA Domain Transcription FactorsTranscription Factorsacute kidney injuryinflammationmitochondrianecroptosis

Identifiers

PMID39781453
PMCPMC11705647

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.