Evidence map›Paper›PMID 39781734›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2025

Marine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer Therapy.

Vijay Murali Ravi Mythili, K Kumaran, Sayantani Chattopadhyay, Shahjahan Ahmad Basha, Sruthi Sekar, Sowmya Senthil, D Prabhu, Kirubakaran Rangasamy, K N ArulJothi

Abstract read
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In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vijay Murali Ravi MythiliDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
K KumaranDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
Sayantani ChattopadhyayDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
Shahjahan Ahmad BashaDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
Sruthi SekarDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
Sowmya SenthilDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.
D PrabhuDepartment of Biotechnology, Centre for Bioinformatics, Karpagam Academy of Higher Education, Coimbatore, 641021, India.
Kirubakaran RangasamyDepartment of Biotechnology, Vinayaka Mission's Kirupananda Variyar Engineering College, Vinayaka Mission's Research Foundation, Salem, 636308, Tamilnadu, India.
K N ArulJothiDepartment of Genetic Engineering, Integrated Genetics and Molecular Oncology Group, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamilnadu, 603203, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe marine habitat is a plentiful source of diverse, active compounds that are extensively utilised for their medicinal properties. Pharmaceutical trends have currently changed towards utilising a diverse range of goods derived from the marine environment.

methodsThis study aimed to examine the inhibitory effects of bioactive chemicals derived from marine algae and bacteria. The identification of these compounds was carried out through the process of Gas Chromatography-Mass Spectrometry (GC-MS) profiling. Subsequently, these compounds were subjected to docking simulations against a specific set of target proteins that are known to be frequently overexpressed in three distinct types of cancer.

resultsFrom the docking results, the ligand 1,4:3,6:5,7-Tribenzal-beta-mannoheptitol was found to be effective against the proteins mTOR (PDB ID: 4JSV) and FGFR2 (PDB ID:6V6Q). The findings of molecular simulation highlight that the investigated compound gets integrated with the target proteins effectively.

conclusionThese marine derived compounds hold significant potential for further development and exploration in the field of cancer therapeutics.

Indexed as

Antineoplastic AgentsBreast NeoplasmsColorectal NeoplasmsLung NeoplasmsReceptor, Fibroblast Growth Factor, Type 2TOR Serine-Threonine KinasesAquatic OrganismsHumansMolecular Docking SimulationAntineoplastic AgentsFGFR2 protein, humanMTOR protein, humanReceptor, Fibroblast Growth Factor, Type 2TOR Serine-Threonine Kinasesbioactive compounds.GC-MSMarine organismsmolecular dockingmolecular simulationstargeted therapy

Identifiers

PMID39781734

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.