Evidence map›Paper›PMID 39781737›Full record

ReviewCurrent pharmaceutical design2026

BACE-1 and ADAM-10 as Potential Peripheral Biomarkers for Alzheimer's Disease.

Carlo Cervellati, Alessandro Trentini, Marco Zuin, Gianmarco Mola, Raffaella Riccetti, Cristina Manfrinato, Domenico Sergi, Gerhard Multhaup, Giovanni Zuliani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlo CervellatiDepartment of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.ORCID 0000-0003-4777-6300
Alessandro TrentiniDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Marco ZuinDepartment of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Gianmarco MolaDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Raffaella RiccettiDepartment of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Cristina ManfrinatoDepartment of Neuroscience and Rehabilitation, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Domenico SergiDepartment of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Gerhard MulthaupDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QCH3G 1Y6, Canada.
Giovanni ZulianiDepartment of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid beta (Aβ) dyshomeostasis is considered the main biological aberration in Alzheimer's Disease (AD) pathology. The interplay between Aβ formation and clearance is predominantly modulated by a disintegrin and a metalloproteinase 10 (ADAM10, α-secretase) and β-site APP Cleaving Enzyme 1 (BACE1), the two pivotal enzymes in both non-amyloidogenic/amyloidogenic and amyloidolytic pathways. Emerging evidence suggests that aberrations in ADAM10 and BACE1 expression, activity, and function in the brain of AD patients also manifest in peripheral fluids, suggesting their potential as blood-based biomarkers for AD diagnosis. This review provides a comprehensive overview of the literature by exploring the roles of ADAM10 and BACE1 in AD, spanning from their involvement as pathological AD drivers to their potential utility as promising biomarkers.

Indexed as

ADAM10 ProteinAlzheimer DiseaseAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesMembrane ProteinsAnimalsBiomarkersHumansADAM10 ProteinADAM10 protein, humanAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanBiomarkersMembrane ProteinsADAM10Alzheimer’s diseaseAβ dyshomeostasisBACE1biomarkersdementia

Identifiers

PMID39781737

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.