Evidence map›Paper›PMID 39785828›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2025

Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity.

Javad Anjom-Shoae, Penelope C E Fitzgerald, Michael Horowitz, Jens J Holst, Jens F Rehfeld, Simon Veedfald, Christine Feinle-Bisset

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Javad Anjom-ShoaeAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0001-5138-0339
Penelope C E FitzgeraldAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0002-2775-9776
Michael HorowitzAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0002-0942-0306
Jens J HolstDepartment of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Jens F RehfeldDepartment of Clinical Biochemistry, Rigshospitalet, DK-2100 Copenhagen, Denmark.
Simon VeedfaldDepartment of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Christine Feinle-BissetAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0001-6848-0125

Funding

Diabetes Australia Research Project Grant 2022-23Independent Research FundNational Health and Medical Research Council of Australia Senior Research Fellowship 1103020National Health and Medical Research Council of Australia Senior Research Fellowship 2016-22University of Adelaide Research Scholarship 2021-25
6 · The paper itself

Abstract

contextIn males of normal weight, intraduodenal administration of calcium enhances the effects of the amino acid L-tryptophan (Trp) to suppress energy intake, associated with greater stimulation of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine-tyrosine (PYY) secretion (key mechanisms underlying the regulation of pyloric motility and gastric emptying) but not gastrin or glucose-dependent insulinotropic polypeptide (GIP).

objectiveGiven the implications for the management of obesity, the current study evaluated the effects of calcium, when administered alone and in combination with Trp, on gut hormone secretion, antropyloroduodenal motility, and energy intake in males with obesity.

methodsFifteen males with obesity and without type 2 diabetes (mean ± SD; age: 27 ± 8 years; body mass index: 30 ± 2 kg/m2; hemoglobin A1c: 5.3 ± 0.2%), received 150-minute intraduodenal infusions of 0, 500, or 1000 mg calcium, each combined with Trp (load: 0.1 kcal/min, known to have submaximal energy-intake suppressant effects) from t = 75-150 minutes, on 3 separate occasions, in a randomized, double-blind, cross-over order. Plasma concentrations of gastrin, CCK, GIP, GLP-1, PYY, and pyloric pressures were measured during the infusions. Immediately postinfusion (t = 150-180 minutes), energy intake at a standardized buffet-style lunch was quantified.

resultsCalcium, in a dose of 1000 mg, stimulated GLP-1, PYY, and pyloric pressures alone (all P < .05) and enhanced the effects of Trp to stimulate CCK, GLP-1, and PYY (all P < .05), associated with greater suppression of energy intake (P = .01). Energy intake (R = -0.64; P = .001) was inversely related to the dose of calcium, while plasma concentrations of CCK (R = 0.44; P = .05), GLP-1 (R = 0.60; P = .01), and PYY (R = 0.83; P = .01) were directly related.

conclusionIntraduodenal calcium enhances the effect of intraduodenal Trp to stimulate CCK, GLP-1, and PYY and suppress energy intake in males with obesity.

Indexed as

CalciumEnergy IntakeGastrointestinal HormonesObesityTryptophanAdultCholecystokininCross-Over StudiesDose-Response Relationship, DrugGastric EmptyingGastrointestinal MotilityGlucagon-Like Peptide 1HumansMaleYoung AdultCalciumCholecystokininGastrointestinal HormonesGlucagon-Like Peptide 1Tryptophanamino acidcholecystokininfood intakeglucagon-like peptide-1gut functionspeptide tyrosine tyrosine

Identifiers

PMID39785828
PMCPMC12342367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.