Evidence map›Paper›PMID 39786607›Full record

ArticleTransgenic research2025

Development of a new flippase-dependent mouse model for red fluorescence-based isolation of KRAS

Dusan Hrckulak, Jakub Onhajzer, Michaela Krausova, Monika Stastna, Vitezslav Kriz, Lucie Janeckova, Vladimir Korinek

Abstract read
In one paragraph

Article in Transgenic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dusan Hrckulak *Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Jakub Onhajzer *Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Michaela KrausovaLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Monika StastnaLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Vitezslav KrizLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Lucie JaneckovaLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Vladimir KorinekLaboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic. vladimir.korinek@img.cas.cz.

Funding

Grantová Agentura České Republiky 20-31322SMinisterstvo Školství, Mládeže a Tělovýchovy EXCELES, LX22NPO5102
6 · The paper itself

Abstract

Proto-oncogene KRAS, GTPase (KRAS) is one of the most intensively studied oncogenes in cancer research. Although several mouse models allow for regulated expression of mutant KRAS, selective isolation and analysis of transforming or tumor cells that produce the KRAS oncogene remains a challenge. In our study, we present a knock-in model of oncogenic variant KRAS

Indexed as

Luminescent ProteinsProto-Oncogene Proteins p21(ras)Red Fluorescent ProteinAnimalsDisease Models, AnimalDNA NucleotidyltransferasesGene Knock-In TechniquesLung NeoplasmsMiceMice, TransgenicDNA NucleotidyltransferasesHras protein, mouseLuminescent ProteinsProto-Oncogene Proteins p21(ras)Red Fluorescent ProteinColon cancerGene targetingIntestinal organoidsKRAS oncogeneLung cancerMRTX1133 inhibitor

Identifiers

PMID39786607
PMCPMC11717838

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.