ArticleNature communications2025
The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- A lifespan atlas of the killifish testis defines a pronounced mid-age remodeling shift during testicular aging.BMC biology · 2026Article
- Transcriptome Analysis of Different Stages in the Early Ovarian Development of the Greater Amberjack (Animals : an open access journal from MDPI · 2026Article
- Whole-genome Resequencing Reveals the Sex Determination System and Develops a Sex-specific Marker in Fat Greenling (Hexagrammos otakii).Marine biotechnology (New York, N.Y.) · 2026Article
- Deciphering the gonadal cell atlas of Monopterus albus and cell fate during sex reversal based on single-cell RNA sequencing.Stem cell research & therapy · 2025Article
- Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes.Molecular ecology · 2025Article
- The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.Nature communications · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleost fishes. Deciphering how individual sex-determining genes orchestrate sex determination can reveal new actors in sexual development. Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). Concerning sex determination, gdf6Y is expressed by somatic supporting cells of the developing testes. There it induces the male sex in a germ cell-independent manner in contrast to sex determination in zebrafish and the medaka. Looking for downstream effectors of Gdf6Y, we identified besides TGF-β signaling modulators, especially the inhibitor of DNA binding genes id1/2/3, the mRNA decay activator zfp36l2 as a new GDF6 signaling target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.