Evidence map›Paper›PMID 39789731›Full record

ReviewNucleus (Austin, Tex.)2025

Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function

Jason C Choi

Abstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jason C ChoiCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0009-0006-5175-4680

Funding

Cell type-specific function of LMNA during myocardial stress in the development of cardiomyopathyR01HL150019 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2020 to 2023
$1.6M
Dusp4 in the pathogenesis of LMNA cardiomyopathyR00HL118163 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2016 to 2018
$737k
NHLBI NIH HHS R00 HL118163NHLBI NIH HHS R01 HL150019
6 · The paper itself

Abstract

Over the past 25 years, nuclear envelope (NE) perturbations have been reported in various experimental models with mutations in the

Indexed as

CardiomyopathiesLamin Type ANuclear EnvelopeAnimalsHumansLoss of Function MutationLamin Type ALMNA protein, humanAutophagycardiomyocytecardiomyopathyconditional deletionGolgilamin A/Cnuclear envelopenuclear laminsperinuclear space

Identifiers

PMID39789731
PMCPMC11730615

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.