Influence of Multidrug Resistance 1 Gene Variants on Response to Intravenous Methylprednisolone Pulse in Systemic Lupus Erythematosus Patients: Preliminary Results.

Doaa Hassan Sayed Attia, Dalia Ahmed Hamza Dorgham, Ahmed Amin Al Maghraby, Manal Barakat Abdelrazik, Dina Aly Ezzat

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Article in Current rheumatology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Doaa Hassan Sayed AttiaRheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-1349-265X

Dalia Ahmed Hamza DorghamRheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0002-4638-6047

Ahmed Amin Al MaghrabyRheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0001-5393-397X

Manal Barakat AbdelrazikBioChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Dina Aly EzzatClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-3317-4210

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6 · The paper itself

Abstract

INTRODUCTION/

objectivesGenetic variations could explain individual responses to drugs. This case-control study aimed to investigate the association between the multidrug resistance 1 (MDR1) gene exonic single nucleotide variants (SNVs),

methodsReal-time polymerase chain reaction was used. Patients were divided into responders and resistant based on the SLE Disease Activity Index (SLEDAI). The degree of improvement was determined according to a 7-point Likert scale.

resultsThe study included 80 patients: 40 patients with renal flares and 40 patients with extrarenal flares. In patients with extrarenal flares, 71.4% of responders had the CT+TT model of the C1236T variant versus 36.8% of resistant patients (p = 0.028); the T allele was detected in 47.6% of responders versus 23.7% of resistant patients (p = 0.026). Patients with the TT and CT genotypes, TT+CT model, and T allele of the C1236T variant had significant improvement based on the Likert scale compared with the CC genotype, CC model and C allele (p = 0.049, 0.038, 0.010 and <0.001, respectively). In the renal subgroup, patients with the CC genotype and C allele of the C3435T variant had significant improvement based on the Likert scale compared with the CT genotype and T allele (p = 0.028 and 0.046, respectively). Patients with the CC model had significantly lower post-treatment proteinuria compared with the TT+CT model (p = 0.024).

conclusionMDR1 C1236T variant allele and C3435T wild allele seem to enhance the response to glucocorticoids in Egyptian patients with active SLE.

Indexed as

GlucocorticoidsLupus Erythematosus, SystemicMethylprednisoloneAdultATP Binding Cassette Transporter, Subfamily BCase-Control StudiesFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideTreatment OutcomeYoung AdultABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BGlucocorticoidsMethylprednisoloneC1236T variantglucocorticoids(MDR1) genemultidrug resistance 1 geneSystemic lupus erythematosusTT+CT model.

Identifiers

PMID39791158

DOI10.3390/diagnostics12071701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.