Evidence mapPaperPMID 39791230Full record

ArticleHuman gene therapy2025

Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation.

Feng Yuan, Xingshen Sun, Soo Yeun Park, Yinghua Tang, Zehua Feng, Mehrnoosh Ebadi, Yaling Yi, Adriane E Thompson, Joseph D Karippaparambil, John F Engelhardt and 1 more

Abstract read
In one paragraph

Article in Human gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feng YuanDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Xingshen SunDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Soo Yeun ParkDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Yinghua TangDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Zehua FengDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Mehrnoosh EbadiDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Yaling YiDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Adriane E ThompsonDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Joseph D KarippaparambilDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
John F EngelhardtDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Ziying YanDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-8210-5567

Funding

Pulmonary Toxicology FacilityP30ES005605 · UNIVERSITY OF IOWA · 1990 to 2025
$8.8M
Biology of Submucosal Gland Stem Cells in the AirwayR01HL165404 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$740k
Development of novel approaches for gene editing therapies of cystic fibrosisR01HL174593 · UNIVERSITY OF KANSAS MEDICAL CENTER · 2025 to 2025
$623k
Medical Student Summer Research ProgramT35HL166206 · NHLBI · UNIVERSITY OF IOWA · 2023 to 2025
$295k
Development of myotropic human bocavirus vectors for gene therapyR21AI182645 · UNIVERSITY OF KANSAS MEDICAL CENTER · 2025 to 2025
$194k
NHLBI NIH HHS R01 HL165404NHLBI NIH HHS R01 HL174593NHLBI NIH HHS T35 HL166206NIAID NIH HHS R21 AI182645NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Cystic fibrosis (CF) is caused by mutations in the

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorAnimalsAnimals, Genetically ModifiedDisease Models, AnimalFerretsGenes, ReporterGreen Fluorescent ProteinsHumansCystic Fibrosis Transmembrane Conductance Regulatorenhanced green fluorescent proteinGreen Fluorescent ProteinsCFTR knock-outCre-responsive CFTR reactivationcystic fibrosisferret

Identifiers

PMID39791230
PMCPMC12419444

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.