Evidence map›Paper›PMID 39791707›Full record

ArticleCells2024

Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma.

Ibrahim Büdeyri, Olaf Guckelberger, Elsie Oppermann, Dhruvajyoti Roy, Svenja Sliwinski, Felix Becker, Benjamin Struecker, Thomas J Vogl, Andreas Pascher, Wolf O Bechstein and 3 more

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ibrahim BüdeyriDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.ORCID 0000-0002-4200-4566
Olaf GuckelbergerDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
Elsie OppermannDepartment of General, Visceral and Transplant Surgery, Frankfurt University Hospital, 60596 Frankfurt, Germany.ORCID 0000-0002-0409-402X
Dhruvajyoti RoyDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Svenja SliwinskiDepartment of General, Visceral and Transplant Surgery, Frankfurt University Hospital, 60596 Frankfurt, Germany.
Felix BeckerDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.ORCID 0000-0002-1945-3128
Benjamin StrueckerDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.ORCID 0000-0002-4205-9890
Thomas J VoglDepartment of Diagnostic and Interventional Radiology, Frankfurt University Hospital, Goethe University, 60596 Frankfurt, Germany.ORCID 0000-0001-5218-1075
Andreas PascherDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
Wolf O BechsteinDepartment of General, Visceral and Transplant Surgery, Frankfurt University Hospital, 60596 Frankfurt, Germany.
Anna LorentzenDepartment of Biomedicine, Aarhus University, 8200 Aarhus, Denmark.
Mathias HeikenwalderDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Mazen A JuratliDepartment of General, Visceral and Transplant Surgery, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.ORCID 0000-0002-1793-0672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide, with no precise method for early detection. Circulating tumor cells (CTCs) expressing the dynamic polarity of the cytoskeletal membrane protein, ezrin, have been proposed to play a crucial role in tumor progression and metastasis. This study investigated the diagnostic and prognostic potential of polarized circulating tumor cells (p-CTCs) in HCC patients. CTCs were isolated from the peripheral blood of 20 HCC patients and 18 patients with nonmalignant liver disease (NMLD) via an OncoQuick

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularCytoskeletal ProteinsLiver NeoplasmsNeoplastic Cells, CirculatingAdultAgedCell PolarityEzrinFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorCytoskeletal ProteinsEzrincancercirculating tumor cellsezrinhepatocellular carcinomaliver surgerypersonalized diagnosis and therapypolarizationsingle-cell polarity

Identifiers

PMID39791707
PMCPMC11720075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.