Evidence map›Paper›PMID 39791721›Full record

ArticleCells2024

Identification of B Cell Subpopulations with Pro- and Anti-Tumorigenic Properties in an Immunocompetent Mouse Model of Head and Neck Squamous Cell Carcinoma.

Michael Sonntag, Sandra Stanojevic, Simon Laban, Patrick J Schuler, Thomas K Hoffmann, Cornelia Brunner

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael SonntagDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.
Sandra StanojevicDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.
Simon LabanDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.ORCID 0000-0001-6732-7137
Patrick J SchulerDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.ORCID 0000-0002-1065-8709
Thomas K HoffmannDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.
Cornelia BrunnerDepartment of Otorhinolaryngology, Ulm University Medical Center, 89075 Ulm, Germany.ORCID 0000-0002-6456-5508

Funding

Deutsche Forschungsgemeinschaft BR 289111-1 and SCHU 25639-1
6 · The paper itself

Abstract

Due to their high developmental diversity and different regulatory and functional roles, B cell subpopulations can promote or inhibit tumor growth. An orthotopic murine HNSCC model was applied to investigate the B cell composition and function in HNSCCs. Using flow cytometry approaches, cells from the spleen, lymph nodes and tumors were analyzed. Additionally, immunoglobulin (Ig) levels post-tumor induction were tracked via enzyme-linked immunosorbent assays (ELISA). Following tumor induction, GCs, as well as increasing numbers of GL7

Indexed as

B-Lymphocyte SubsetsCarcinogenesisHead and Neck NeoplasmsImmunocompetenceSquamous Cell Carcinoma of Head and NeckAdenosineAnimalsDisease Models, AnimalGerminal CenterImmunoglobulinsLymph NodesLymphocyte ActivationLymphocyte CountMaleMice, Inbred C3HSpleenAdenosineImmunoglobulinsadenosineB cellsgerminal centersHNSCCimmunocompetent mouse model

Identifiers

PMID39791721
PMCPMC11720715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.