Evidence map›Paper›PMID 39791987›Full record

ArticleChembiochem : a European journal of chemical biology2025

Interplay between C

Thomas W Harmon, Yuhan Lin, Ryen T Sutton, Shane W J Osborne, W Seth Horne

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Interplay between CChembiochem : a European journal of chemical biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas W HarmonDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Yuhan LinDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Ryen T SuttonDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Shane W J OsborneDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
W Seth HorneDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID https://orcid.org/0000-0003-2927-1739

Funding

Exploring the Impact of Altered Backbone Composition on Protein Folding and FunctionR35GM149220 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILLIAM SETH HORNE · 2023 to 2026
$1.4M
NIGMS NIH HHS R35 GM149220NIH HHS R35GM149220
6 · The paper itself

Abstract

The α-helix is an abundant and functionally important element of protein secondary structure, which has motivated intensive efforts toward chemical strategies to stabilize helical folds. One such method is the incorporation of non-canonical backbone composition through an additional methyl substituent at the C

Indexed as

PeptidesAminoisobutyric AcidsMethylationProtein Conformation, alpha-HelicalProtein FoldingStereoisomerismThermodynamics2-aminoisobutyric acidAminoisobutyric AcidsPeptidesHeterogeneous backbonesMiniproteinPeptidomimeticProteomimeticα-Helix

Identifiers

PMID39791987
PMCPMC11907383

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.