ArticlePloS one2025
Sex differences in the association between composite dietary antioxidant index and hyperlipidemia: Insights from NHANES.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance.Journal of the International Society of Sports Nutrition · 2026Review
- Nonlinear association of a body shape index and hyperlipidemia: an American population-based cross-sectional study.Annals of medicine · 2025Article
- Potassium and survival outcomes in asthma patients: evidence from a retrospective cohort study.Journal of thoracic disease · 2025Article
- Vitamin Status and Risk of Age-Related Diseases Among Adult Residents of the Pearl River Delta Region.Nutrients · 2025Article
- Protective effect of dietary phosphorus intake on cardiovascular mortality in asthma: evidence from NHANES 1999-2018.Frontiers in nutrition · 2025Article
- Gender difference in the association between composite dietary antioxidant index and all-cause mortality.Frontiers in nutrition · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundPrevious studies have shown that both the composite dietary antioxidant index (CDAI) and sex are strongly associated with a variety of cardiovascular diseases, but sex differences between CDAI and hyperlipidemia are unknown.
objectiveThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) to investigate the sex differences between CDAI and hyperlipidemia.
methodWe calculated the CDAI of the six dietary antioxidants using data from NHANES, explored the relationship between CDAI and the prevalence of hyperlipidemia using multivariate logistic regression analysis, and analyzed for potential nonlinear associations using restricted cubic spline. Finally, the association between CDAI and hyperlipidemia was further explored using multivariate logistic regression in different genders.
resultsThe study included a total of 34,754 participants with a mean age of 47.04 years, of whom 49.37% were man. In a fully adjusted multivariable binary logistic regression model, CDAI was negatively associated with the prevalence of hyperlipidemia (OR = 0.99, 95% CI:0.98-0.99). In addition, participants in the highest quartile had a lower risk of hyperlipidaemia compared with the lowest quartile of CDAI (OR = 0.83, 95%CI: 0.76-0.92). We also found a non-linear relationship (non-linear P = 0.003, Inflection point = -0.179). Finally, we found that the association between CDAI and the prevalence of hyperlipidemia was significantly stronger in the female population than in the male population (P for interaction <0.05).
conclusionOur study highlights the L-shaped association between CDAI and the prevalence of hyperlipidemia in the general adult population. In addition, this association was more significant in the female population than in the male population.
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