Evidence map›Paper›PMID 39794135›Full record

ArticleAJNR. American journal of neuroradiology2025

Fusion of FDG and FMZ PET Reduces False-Positives in Predicting Epileptogenic Zone.

Bingyang Cai, Shize Jiang, Hui Huang, Jiwei Li, Siyu Yuan, Ya Cui, Weiqi Bao, Jie Hu, Jie Luo, Liang Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bingyang CaiFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
Shize JiangDepartment of Neurosurgery (S.J., J.H., L.C.), Huashan Hospital, Fudan University, Shanghai, China.
Hui HuangFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
Jiwei LiFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-1847-7232
Siyu YuanFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
Ya CuiFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
Weiqi BaoPET Center (W.B.), Huashan Hospital, Fudan University, Shanghai, China.
Jie HuDepartment of Neurosurgery (S.J., J.H., L.C.), Huashan Hospital, Fudan University, Shanghai, China.
Jie LuoFrom the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China jieluo@sjtu.edu.cn.
Liang ChenDepartment of Neurosurgery (S.J., J.H., L.C.), Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeEpilepsy, a globally prevalent neurologic disorder, necessitates precise identification of the epileptogenic zone (EZ) for effective surgical management. While the individual utilities of FDG-PET and flumazenil (FMZ)-PET have been demonstrated, their combined efficacy in localizing the epileptogenic zone remains underexplored. We aim to improve the noninvasive prediction of EZ in temporal lobe epilepsy (TLE) by combining FDG-PET and FMZ-PET with statistical feature extraction and machine learning. MATERIALS AND

methodsThis study included 20 drug-resistant patients with unilateral TLE (14 mesial TLE, 6 lateral TLE) and 2 control groups (

resultsFDG SUVR significantly decreased in EZ and PZ compared with NIZ, while FMZ SUVR in EZ significantly differed from PZ. Interaction effects were found between FDG and FMZ in their prediction of epileptogenicity. Fusion of FDG and FMZ provided the best prediction model with an area under the curve (AUC) of 0.86 [0.84-0.87] for EZ versus NIZ and an AUC of 0.79 [0.77-0.81] for EZ versus PZ, eliminating 100% false-positives in 50% of patients, and ≥80% FPs in 90% of patients at patient level.

conclusionsCombined FDG and FMZ offer a promising avenue for noninvasive localization of the epileptogenic zone in TLE, potentially refining surgical planning.

Indexed as

Drug Resistant EpilepsyEpilepsy, Temporal LobeFlumazenilFluorodeoxyglucose F18Multimodal ImagingPositron-Emission TomographyAdultFalse Positive ReactionsFemaleHumansMaleMiddle AgedRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityYoung AdultFlumazenilFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID39794135
PMCPMC12453447

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.