Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Karina Costa da SilvaLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.
Irlã Santos LimaLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.ORCID 0009-0002-4394-0070
Cleonice Creusa Dos SantosLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.
Carolina Kymie Vasques NonakaCenter of Biotechnology and Cell Therapy, São Rafael Hospital, D'Or Institute for Research and Teaching, Salvador 41253-190, BA, Brazil.ORCID 0000-0002-1609-9469
Bruno Solano de Freitas SouzaCenter of Biotechnology and Cell Therapy, São Rafael Hospital, D'Or Institute for Research and Teaching, Salvador 41253-190, BA, Brazil.
Jorge Mauricio DavidDepartment of General and Inorganic Chemistry, Institute of Chemistry, Federal University of Bahia, Salvador 40231-300, BA, Brazil.ORCID 0000-0001-6375-9055
Henning UlrichDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes, 748-Butantã, São Paulo 05508-900, SP, Brazil.ORCID 0000-0002-2114-3815
Ravena Pereira do NascimentoLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-2915-3030
Maria de Fátima Dias CostaLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.
Balbino Lino Dos SantosLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-6430-229X
Silvia Lima CostaLaboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-8975-3871
Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior Process 88887.473627/2020-00Fundação de Amparo à Pesquisa do Estado da Bahia Process No. DCR 0001/2024 ; Process RED0013/2024;Fundação de Amparo à Pesquisa do Estado de São Paulo Process Nº 2023/17147-6National Council for Scientific and Technological Development Processes No. 312388/2021-7
6 · The paper itself
Abstract
Glioblastomas (GBM) are malignant tumours with poor prognosis. Treatment involves chemotherapy and/or radiotherapy; however, there is currently no standard treatment for recurrence, and prognosis remains unfavourable. Inflammatory mediators and microRNAs (miRNAs) influence the aggressiveness of GBM, being involved in the communication with the cells of the tumour parenchyma, including microglia/macrophages, and maintaining an immunosuppressive microenvironment. Hence, the modulation of miRNAs and inflammatory factors may improve GBM treatments. In this study, we investigated the effects of agathisflavone, a biflavonoid purified from
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation. · full record | Socratic