Evidence map›Paper›PMID 39795860›Full record

ArticleInternational journal of molecular sciences2024

Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.

Islam Ibrahim Hegab, Hemat El-Sayed El-Horany, Rania Nagi Abd-Ellatif, Nahla Anas Nasef, Asmaa H Okasha, Marwa Nagy Emam, Shereen Hassan, Walaa S Elseady, Doaa A Radwan, Rasha Osama ElEsawy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Islam Ibrahim HegabPhysiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Hemat El-Sayed El-HoranyMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Rania Nagi Abd-EllatifMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Nahla Anas NasefMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0002-7183-6046
Asmaa H OkashaMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Marwa Nagy EmamPhysiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Shereen HassanPhysiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Walaa S ElseadyAnatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Doaa A RadwanAnatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Rasha Osama ElEsawyPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Yasser Mostafa HafezInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Maha Elsayed HassanInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Nouran Mostafa MansourCardiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Gamaleldien Elsayed AbdelkaderDepartment of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan.ORCID 0009-0004-8305-6196
Mohamed H FoudaClinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Amira M Abd El MagedPathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom 32511, Egypt.ORCID 0009-0005-2357-0166
Hanan M AbdallahPhysiology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential of adropin and/or tirzepatide (Tirze) on cardiometabolic aberrations in the letrozole-induced PCOS model. Female Wistar non-pregnant rats were allotted into five groups: CON; PCOS; PCOS + adropin; PCOS + Tirze; and PCOS + adropin+ Tirze. The serum sex hormones, glucose, and lipid profiles were securitized. Cardiac phosphorylated levels of AKT(pAKT), glycogen synthase kinase-3 beta (pGSK-3β), NOD-like receptor family pyrin domain containing 3 (NLPR3), IL-1β and IL-18 were assayed. The cardiac redox status and endoplasmic reticulum stress (ER) parameters including relative glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) gene expressions were detected. Finally, the immunoreactivity of cardiac NF-κB, Bcl2, and BAX were assessed. Our results displayed that adropin and/or Tirze intervention successfully alleviated the PCOS-provoked cardiometabolic derangements with better results recorded for the combination treatment. The synergistic effect of adropin and Tirze is mostly mediated via activating the cardiac Akt, which dampens the GSK3β/NF-κB/NLRP3 signaling pathway, with a sequel of alleviating oxidative damage, inflammatory response, ER stress, and related apoptosis, making them alluring desirable therapeutic targets in PCOS-associated cardiac complications.

Indexed as

NLR Family, Pyrin Domain-Containing 3 ProteinPeptidesPolycystic Ovary SyndromeAnimalsBlood ProteinsDisease Models, AnimalEndoplasmic Reticulum StressFemaleGlycogen Synthase Kinase 3 betaMyocardiumNF-kappa BProto-Oncogene Proteins c-aktRatsRats, WistarSignal TransductionTirzepatideBlood ProteinsENHO protein, ratGlycogen Synthase Kinase 3 betaNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratPeptidesProto-Oncogene Proteins c-aktTirzepatideadropinapoptosiscardiovascularinflammationpolycystic ovarian syndrometirzepatide

Identifiers

PMID39795860
PMCPMC11720588

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.