ArticleInternational journal of molecular sciences2024
The Anti-Obesity Effect of Fish Oil in Diet-Induced Obese Mice Occurs via Both Decreased Food Intake and the Induction of Heat Production Genes in Brown but Not White Adipose Tissue.
Takahiko Obo, Hiroshi Hashiguchi, Eriko Matsuda, Shigeru Kawade, Kazuma Ogiso, Haruki Iwai, Koji Ataka, Osamu Yasuda, Aiko Arimura, Takahisa Deguchi and 3 more
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In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Takahiko OboDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0009-0000-7315-4199 Hiroshi HashiguchiDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Eriko MatsudaDepartment of Gene Therapy and Regenerative Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Shigeru KawadeDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Kazuma OgisoDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Haruki IwaiDepartment of Oral Anatomy and Cell Biology, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0002-2698-3522 Koji AtakaDepartment of Health and Nutrition, Faculty of Nursing and Nutrition, Kagoshima Immaculate Heart University, Kagoshima 895-0011, Japan.
Osamu YasudaDepartment of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, Kanoya 891-2311, Japan.ORCID 0000-0003-4726-5666 Aiko ArimuraDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0009-0005-3517-6828 Takahisa DeguchiDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0002-4769-2193 Katsutaro MorinoDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0003-2420-3817 Akihiro AsakawaDepartment of Psychosomatic Internal Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Yoshihiko NishioDepartment of Diabetes and Endocrine Medicine, Graduate School of Medicine and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Omega-3 (ω-3) polyunsaturated fatty acids in fish oil have been shown to prevent diet-induced obesity in lean mice and to promote heat production in adipose tissue. However, the effects of fish oil on obese animals remain unclear. This study investigated the effects of fish oil in obese mice. C57BL/6J mice were fed a lard-based high-fat diet (LD) for 8 weeks and then assigned to either a fish oil-based high-fat diet (FOD) or continued the LD for additional 8 weeks. A control group was fed a standard diet for 16 weeks. Mice fed the FOD showed weight loss, reduced adipose tissue mass, and lower plasma insulin and leptin levels compared to those fed the LD. Rectal temperatures were higher in the FOD and LD groups compared to the control group. Energy intake was lower in the FOD group than the LD group but similar to the control group. The FOD and LD groups exhibited increased expression of heat-producing genes such as
Indexed as
Adipose Tissue, BrownAdipose Tissue, WhiteAnti-Obesity AgentsEatingFish OilsObesityThermogenesisAnimalsDiet, High-FatInsulinLeptinMaleMiceMice, Inbred C57BLMice, ObesePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnti-Obesity AgentsFish OilsInsulinLeptinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR alphaReceptors, Adrenergic, beta-3Ucp1 protein, mouseUncoupling Protein 1brown adipose tissuediet-induced obesityomega-3 polyunsaturated fatty acidswhite adipose tissue
Identifiers
PMID39796158
PMCPMC11719521
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