Evidence map›Paper›PMID 39796190›Full record

ReviewInternational journal of molecular sciences2025

Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management.

Giuseppina Gallucci, Mario Larocca, Alessandro Navazio, Fabio Maria Turazza, Alessandro Inno, Maria Laura Canale, Stefano Oliva, Giulia Besutti, Andrea Tedeschi, Daniela Aschieri and 5 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Long-Term Cardiovascular Toxicity of Immunotherapy: Too Important to Ignore.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giuseppina GallucciIndependent Researcher, 85025 Melfi, Italy.
Mario LaroccaProvincial Medical Oncology, Department of Oncology and Advanced Technologies, AUSL-IRCCS in Tecnologie Avanzate e Modelli Assistenziali in Oncologia, 42100 Reggio Emilia, Italy.
Alessandro NavazioCardiologia Ospedaliera, Department of Specialized Medicine, AUSL-IRCCS in Tecnologie Avanzate e Modelli Assistenziali in Oncologia, 42100 Reggio Emilia, Italy.ORCID 0000-0001-8417-7783
Fabio Maria TurazzaIndependent Researcher, 50100 Firenze, Italy.
Alessandro InnoOncologia Medica, IRCCS Ospedale Sacro Cuore Don Calabria, 37024 Negrar di Valpolicella, Italy.ORCID 0000-0001-6331-6908
Maria Laura CanaleDivision of Cardiology, Azienda USL Toscana Nord-Ovest, Versilia Hospital, 55041 Lido di Camaiore, Italy.
Stefano OlivaUOSD Cardiologia di Interesse Oncologico IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Giulia BesuttiRadiology Unit, Department of Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, 42100 Reggio Emilia, Italy.ORCID 0000-0001-5319-5495
Andrea TedeschiCardiology Unit of Emergency Department, Guglielmo da Saliceto Hospital, 29100 Piacenza, Italy.ORCID 0000-0003-0315-3304
Daniela AschieriCardiology Unit of Emergency Department, Guglielmo da Saliceto Hospital, 29100 Piacenza, Italy.
Antonio RussoDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-4370-2008
Stefania GoriOncologia Medica, IRCCS Ospedale Sacro Cuore Don Calabria, 37024 Negrar di Valpolicella, Italy.ORCID 0000-0001-6320-405X
Nicola SilvestrisMedical Oncology Department, IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Carmine PintoProvincial Medical Oncology, Department of Oncology and Advanced Technologies, AUSL-IRCCS in Tecnologie Avanzate e Modelli Assistenziali in Oncologia, 42100 Reggio Emilia, Italy.ORCID 0000-0002-3159-5268
Luigi TarantiniCardiologia Ospedaliera, Department of Specialized Medicine, AUSL-IRCCS in Tecnologie Avanzate e Modelli Assistenziali in Oncologia, 42100 Reggio Emilia, Italy.ORCID 0000-0003-2580-0963

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first part of this review highlighted the evolving landscape of atherosclerosis, noting emerging cardiometabolic risk factors, the growing impact of exposomes, and social determinants of health. The prominent role of atherosclerosis in the bidirectional relationship between cardiovascular disease and cancer was also discussed. In this second part, we examine the complex interplay between multimorbid cardio-oncologic patients, cardiometabolic risk factors, and the harmful environments that lend a "syndemic" nature to these chronic diseases. We summarize management strategies targeting disordered cardiometabolic factors to mitigate cardiovascular disease and explore molecular mechanisms enabling more tailored therapies. Importantly, we emphasize the early interception of atherosclerosis through multifactorial interventions that detect subclinical signs (via biomarkers and imaging) to treat modifiable risk factors and prevent clinical events. A concerted preventive effort-referred to by some as a "preventome"-is essential to reduce the burden of atherosclerosis-driven chronic diseases, shifting from mere chronic disease management to the proactive promotion of "chronic health".

Indexed as

AtherosclerosisCardiovascular DiseasesNeoplasmsAnimalsBiomarkersDisease ManagementHumansRisk FactorsBiomarkersatherosclerosiscancercardiovascular diseaseexposomepreventomesyndemic

Identifiers

PMID39796190
PMCPMC11719480

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.